Publications
Impact of cardiometabolic factors and AD plasma biomarkers on white matter hyperintensities volume in individuals with cognitive complaints from the global south.
Riquelme-Contreras P, Henriquez F, Gonzalez-Campo C, Altschuler F, Fraile-Vazquez M, Ferreira PCL, Bellaver B, Karikari TK, Pascoal TA, Okuma C, Gonzalez-Billault C, Court FA, Cerda M, Lillo P, Durán-Aniotz C, Khondoker M, Hornberger M, Slachevsky A. Impact of...
Evaluating Plasma p-tau217 as an Endpoint for Alzheimer Disease Clinical Trials.
Ferreira PCL, Bellaver B, Povala G, Bauer-Negrini G, Aguzzoli CS, Ferrari-Souza JP, Leffa DT, Soares C, Lussier FZ, Medeiros MS, Felix C, Ruppert E, Rohden F, Borelli WV, Karim HT, Langhough R, Christian BT, Wilson R, Hong CH, Roh HW, Patira R, Tudorascu DL, Zimmer...
Plasma p-tau212 identifies cognitively unimpaired individuals with emerging amyloid-β pathology
Kac PR, González-Escalante A, Milà-Alomà M, Ashton NJ, Shekari M, Ortiz-Romero P, Turton M, Harrison P, Zetterberg H, Gispert JD, Karikari TK, Suárez-Calvet M, Blennow K. Plasma p-tau212 identifies cognitively unimpaired individuals with emerging amyloid-β pathology....
Plasma biomarkers, brain amyloid-beta pathology, and cortical thickness in a non-Hispanic White and Black/African American middle-aged community cohort: The HCP-CoBRA study
Brodman ST, Heaton N, Triana-Baltzer G, Zeng X, Gogola A, Kamboh MI, Villemagne VL, Lopez OL, Kolb H, Deek RA, Cohen AD, Karikari TK. Plasma biomarkers, brain amyloid-beta pathology, and cortical thickness in a non-Hispanic White and Black/African American middle-aged...
Plasma soluble TREM2 is associated with plasma pTau-181 and pTau-231 in cognitively normal older adults at risk of Alzheimer’s disease.
Asih PR, Morris CW, Wang H, Pedrini S, Goozee K, Laws SM, Chatterjee P, Taddei K, Sohrabi HR, Rainey-Smith SR, Lim CK, Guillemin GJ, Karikari TK, Masters CL, Zetterberg H, Blennow K, Ashton NJ, Martins RN. Plasma soluble TREM2 is associated with plasma pTau-181 and...
Saliva phosphorylated tau concentration is not associated with Alzheimer’s disease, cerebrospinal fluid or blood biomarkers.
Gleerup HS, Sanna F, Koutarapu S, Lantero-Rodriguez J, Montoliu-Gaya L, Hanrieder J, Brinkmalm G, Karikari TK, Simren J, Høgh P, Blennow K, Hasselbalch SG, Zetterberg H, Ashton NJ, Simonsen AH. Saliva phosphorylated tau concentration is not associated with Alzheimer's...
Clinical Validation of Novel Immunoassays for Plasma Phosphorylated Tau 217, 212, 181, 231, and Brain-Derived Tau Across the Biochemical Spectrum of Alzheimer’s Disease.
Dulewicz M, Kac PR, Ortiz FG, Karikari TK, Kulczyńska-Przybik A, Mroczko B, Turton M, Harrison P, Maler M, Oberstein T, Kornhuber J, Hanrieder J, Zetterberg H, Blennow K, Lewczuk P. Clinical Validation of Novel Immunoassays for Plasma Phosphorylated Tau 217, 212, 181,...
Treatment-related amyloid clearance (TRAC): a framework to characterize patients in the era of anti-amyloid therapies
La Joie R, Cummings JL, Dage JL, Galasko D, Ikonomovic MD, Karikari TK, Landau SM, Llibre-Guerra JJ, Mummery CJ, Ossenkoppele R, Price JC, Risacher SL, Smith R, van Dyck CH, Carrillo MC. Treatment-related amyloid clearance (TRAC): a framework to characterize patients...
Cross-cohort validation and cutpoint estimation of the Janssen plasma p-tau217+ assay in predominantly cognitively normal community studies
Balogun WG, Zeng X, Triana-Baltzer G, Saeed A, Aigbogun HE, Gogola A, Lopresti BJ, Villemagne VL, Ganguli M, Kolb H, Snitz BE, Lopez OL, Cohen AD, Reis SE, Karikari TK. Cross-cohort validation and cutpoint estimation of the Janssen plasma p-tau217+ assay in...
APOE ε4 potentiates tau related reactive astrogliosis assessed by cerebrospinal fluid YKL40 in Alzheimer’s disease.
Trudel L, Therriault J, Macedo AC, Woo MS, Rahmouni N, Aumont É, Servaes S, Hosseini SA, Ferrari-Souza JP, Bellaver B, Ferreira PL, Chan T, Wang YT, Fernandez-Arias J, Zheng Y, Hall B, Stevenson J, Hopewell R, Hsiao CH, Montembeault M, Klostranec J, Iturria-Medina Y,...
The Neighborhoods Study: Examining the social exposome in Alzheimer’s disease and related dementias.
George GC, Keller SA, Abner E, Adar S, Alosco ML, Apostolova LG, Bakulski K, Barnes LL, Bateman JR, Batterman S, Beach TG, Bendlin BB, Bennett DA, Betthauser TJ, Brewer J, Buckingham W, Carrión CI, Chodosh J, Craft S, Croff R, Fabio A, Farias ST, Feldman EL, Goldstein...
Plasma vs. serum: which is better for proteomic blood biomarker analysis? Evaluation of the novel NULISA platform
Farinas MF, Chen Y, Zeng X, Nafash MN, Cohen AD, Lopez OI, Karikari TK. Plasma vs. serum: which is better for proteomic blood biomarker analysis? Evaluation of the novel NULISA platform. medRxiv [Preprint]. 2025 Nov 9:2025.11.08.25339626. doi:...
Classification accuracies of plasma ptau217 vs. ptau217/Aβ1-42 for brain Aβ pathology in cognitively normal older adults.
Olvera-Rojas, M., Solis-Urra, P., Fernandez-Gamez, B., Coca-Pulido, A., Triviño-Ibáñez, E. M., Zeng, X., Oberlin, L. E., Gispert, J. D., Erickson, K. I., Gómez-Río, M., Karikari, T. K., Ortega, F. B., & Esteban-Cornejo, I. (2025). Classification accuracies of...
Understanding Cerebral Blood Flow Dynamics for Alzheimer’s Disease Prevention Through Acute Exercise (flADex): Protocol for a Randomized Crossover Trial.
Martín-Fuentes, I., Fernandez-Gamez, B., Vidal-Almela, S., Caro-Rus, A., Solis-Urra, P., Sánchez-Aranda, L., Fernández-Ortega, J., Sanchez-Martinez, J., Coca-Pulido, A., Olvera-Rojas, M., Barranco-Moreno, E. J., Marin-Alvarez, J. D., Bakker, E. A., Toval, A., Bellón,...
Equivalence of the FCSRT and RAVLT to detect medial Temporal lobe atrophy and tauopathy.
Aumont E, Amiel K, Lopez DO, Arias JF, Montembeault M, Bezgin G, Hall BJ, Trudel L, Chan T, Rahmouni N, Stevenson J, Servaes S, Macedo AC, Hosseini SA, Vitali P, Poltronetti NM, Klostranec J, Therriault J, Benedet AL, Ashton NJ, Zetterberg H, Blennow K, Karikari TK,...
Association Between the Genetic Risk for Attention-Deficit/Hyperactivity Disorder and Cognitive Function in Older Age: The MYHAT Population-Based Study.
Leffa, D. T., Zhang, Y., Wang, Y., Teverovsky, E. G., Jacobsen, E., Bellaver, B., Ferreira, P. C. L., Fan, K. H., Kamboh, M. I., Karikari, T. K., Chang, C. H., Snitz, B. E., Molina, B. S. G., Pascoal, T. A., & Ganguli, M. (2025). Association Between the Genetic...
Amyloid beta and tau are associated with the dual effect of neuroinflammation on neurodegeneration
Povala G, Bellaver B, Bastiani MA, Ferrari-Souza JP, Aguzzoli CS, Leffa DT, Ferreira PCL, Lussier FZ, Rocha A, Zalzale H, Soares C, Bauer-Negrini G, Therriault J, Rahmouni N, Stevenson J, Servaes S, Tissot C, Zatt B, Karikari TK, Ikonomovic MD, Villemagne VL, Gauthier...
Head-to-head comparison of plasma p-tau217 immunoassays for incipient Alzheimer’s disease in community cohorts.
Deek RA, Balogun WG, Zeng X, Pascoal TA, Karikari TK, Cohen AD, Snitz B, Triana-Baltzer G, Kolb HC. Head-to-head comparison of plasma p-tau217 immunoassays for incipient Alzheimer's disease in community cohorts. medRxiv [Preprint]. 2025 Oct 9:2025.10.07.25337434. doi:...
Cohort profile: A community-based prospective cohort study of Alzheimer’s disease and related dementias in the Democratic Republic of Congo
Ikanga J, Obenauf C, Patel SS, Schwinne M, Gikelekele G, Epenge E, Potshi JM, Tomadia T, Kazadi J, Kavugho I, Santolini GL, Sabowa FM, Musewu BM, Mawisa E, Tsangu JP, Beya FMK, Mampunza S, Mananga L, Bukabau J, Teunissen CE, Karikari T, Gross AL, Rojas JC, Alonso A....
CSF total tau as a proxy of synaptic degeneration.
Soares, C., Bellaver, B., Ferreira, P. C. L., Povala, G., Schaffer Aguzzoli, C., Ferrari-Souza, J. P., Zalzale, H., Lussier, F. Z., Rohden, F., Abbas, S., Bauer-Negrini, G., Teixeira Leffa, D., Benedet, A. L., Langhough, R., Betthauser, T. J., Christian, B. T.,...
Associations of 18 F-RO-948 Tau PET with Fluid AD Biomarkers, Centiloid, and Cognition in the Early AD Continuum
Shekari M, González Escalante A, Milà-Alomà M, Falcon C, López-Martos D, Sánchez-Benavides G, Brugulat-Serrat A, Niñerola-Baizán A, Ashton NJ, Karikari TK, Lantero-Rodriguez J, Montoliu-Gaya L, Snellman A, Day TA, Dage JL, Ortiz-Romero P, Tonietto M, Borroni E, Klein...
Plasma biomarkers, brain amyloid pathology, and cortical thickness in a diverse middle-aged community cohort: the HCP-CoBRA study
Brodman ST, Heaton N, Triana-Baltzer G, Zeng X, Gogola A, Kamboh MI, Villemagne VL, Lopez OL, Kolb H, Deek RA, Cohen AD, Karikari TK. Plasma biomarkers, brain amyloid pathology, and cortical thickness in a diverse middle-aged community cohort: the HCP-CoBRA study....
Blood phosphorylated tau for the diagnosis of Alzheimer’s disease: a systematic review and meta-analysis
Therriault J, Brum WS, Trudel L, Macedo AC, Bitencourt FV, Martins-Pfeifer CC, Nakouzi M, Pola I, Wong M, Kac PR, Real AP, Witherow C, Karikari TK, Moscoso A, Zimmer ER, Schöll M, Pascoal T, Benedet AL, Ashton NJ, Schindler SE, Zetterberg H, Blennow K, Rosa-Neto P....
Diagnosis of Alzheimer’s disease using plasma biomarkers adjusted to clinical probability
Therriault J, Janelidze S, Benedet AL, Ashton NJ, Arranz Martínez J, Gonzalez-Escalante A, Bellaver B, Alcolea D, Vrillon A, Karim H, Mielke MM, Hyung Hong C, Roh HW, Contador J, Puig Pijoan A, Algeciras-Schimnich A, Vemuri P, Graff-Radford J, Lowe VJ, Karikari TK,...
Arterial stiffness moderates the link between NfL and cognition: The IGNITE study
Norling AM, Lipsitz LA, Dufour AB, Travison TG, Sewell KR, Collins AM, Wan L, Grove G, Huang H, Oberlin LE, Jain S, Karikari TK, Morris JK, Jakicic JM, McAuley E, Kramer AF, Hillman CH, Vidoni ED, Billinger SA, Burns JM, Marsland AL, Kang C, Erickson KI. Arterial...
Plasma brain-derived tau: analytical and clinical validation of the first commercial immunoassay
Nafash MN, Svirsky SE, Zeng X, Chen Y, Kofler J, Cohen AD, Okonkwo DO, Lopez OL, Puccio AM, Karikari TK. Plasma brain-derived tau: analytical and clinical validation of the first commercial immunoassay. medRxiv [Preprint]. 2025 Jul 21:2025.07.21.25331193. doi:...
Alzheimer’s Association Clinical Practice Guideline on the use of blood-based biomarkers in the diagnostic workup of suspected Alzheimer’s disease within specialized care settings
Palmqvist S, Whitson HE, Allen LA, Suarez-Calvet M, Galasko D, Karikari TK, Okrahvi HR, Paczynski M, Schindler SE, Teunissen CE, Zetterberg H, Carrillo MC, Edelmayer RM, Mahinrad S, McAteer MB, Kahale LA, Pahlke S, Tampi MP. Alzheimer's Association Clinical Practice...