Publications
Menopausal vasomotor symptoms and plasma Alzheimer disease biomarkers.
Thurston RC, Maki P, Chang Y, Wu M, Aizenstein HJ, Derby CA, Karikari TK. Am J Obstet Gynecol. 2024 Mar;230(3):342.e1-342.e8. doi: 10.1016/j.ajog.2023.11.002. Epub 2023 Nov 7.
Association of Plasma Brain-Derived Tau With Functional Outcome After Ischemic Stroke.
Stanne TM, Gonzalez-Ortiz F, Brännmark C, Jood K, Karikari T, Blennow K, Jern C. Neurology. 2024 Feb 27;102(4):e209129. doi: 10.1212/WNL.0000000000209129. Epub 2024 Jan 31.
Biological variation estimates of Alzheimer’s disease plasma biomarkers in healthy individuals.
Brum WS, Ashton NJ, Simrén J, di Molfetta G, Karikari TK, Benedet AL, Zimmer ER, Lantero-Rodriguez J, Montoliu-Gaya L, Jeromin A, Aarsand AK, Bartlett WA, Calle PF, Coşkun A, Díaz-Garzón J, Jonker N, Zetterberg H, Sandberg S, Carobene A, Blennow K. Alzheimers Dement....
A novel ultrasensitive assay for plasma p-tau217: Performance in individuals with subjective cognitive decline and early Alzheimer’s disease.
Gonzalez-Ortiz F, Ferreira PCL, González-Escalante A, Montoliu-Gaya L, Ortiz-Romero P, Kac PR, Turton M, Kvartsberg H, Ashton NJ, Zetterberg H, Harrison P, Bellaver B, Povala G, Villemagne VL, Pascoal TA, Ganguli M, Cohen AD, Minguillon C, Contador J, Suárez-Calvet M,...
Plasma pTau-217 and N-terminal tau (NTA) enhance sensitivity to identify tau PET positivity in amyloid-β positive individuals.
Woo MS, Tissot C, Lantero-Rodriguez J, Snellman A, Therriault J, Rahmouni N, Macedo AC, Servaes S, Wang YT, Arias JF, Hosseini SA, Chamoun M, Lussier FZ, Benedet AL, Ashton NJ, Karikari TK, Triana-Baltzer G, Kolb HC, Stevenson J, Mayer C, Kobayashi E, Massarweh G,...
Comparison of immunoassay- with mass spectrometry-derived p-tau quantification for the detection of Alzheimer’s disease pathology.
Therriault J, Woo MS, Salvadó G, Gobom J, Karikari TK, Janelidze S, Servaes S, Rahmouni N, Tissot C, Ashton NJ, Benedet AL, Montoliu-Gaya L, Macedo AC, Lussier FZ, Stevenson J, Vitali P, Friese MA, Massarweh G, Soucy JP, Pascoal TA, Stomrud E, Palmqvist S,...
Levels of plasma brain-derived tau and p-tau181 in Alzheimer’s disease and rapidly progressive dementias.
Gonzalez-Ortiz F, Karikari TK, Bentivenga GM, Baiardi S, Mammana A, Turton M, Kac PR, Mastrangelo A, Harrison P, Capellari S, Zetterberg H, Blennow K, Parchi P. Alzheimers Dement. 2024 Jan;20(1):745-751. doi: 10.1002/alz.13516. Epub 2023 Oct 19.
Longitudinal cerebrospinal fluid measurements show glial hypo- and hyperactivation in predementia Alzheimer’s disease.
Nordengen K, Kirsebom BE, Richter G, Pålhaugen L, Gísladóttir B, Siafarikas N, Nakling A, Rongve A, Bråthen G, Grøntvedt GR, Gonzalez F, Waterloo K, Sharma K, Karikari T, Vromen EM, Tijms BM, Visser PJ, Selnes P, Kramberger MG, Winblad B, Blennow K, Fladby T. J...
Plasma p-tau212: antemortem diagnostic performance and prediction of autopsy verification of Alzheimer’s disease neuropathology.
Kac PR, González-Ortiz F, Emeršič A, Dulewicz M, Koutarapu S, Turton M, An Y, Smirnov D, Kulczyńska-Przybik A, Varma V, Ashton NJ, Montoliu-Gaya L, Camporesi E, Winkel I, Paradowski B, Moghekar A, Troncoso JC, Brinkmalm G, Resnick SM, Mroczko B, Kvartsberg H,...
Clinical Manifestations.
Aguzzoli CS, Ferreira PCL, Povala G, Soares C, Ferrari-Souza JP, Bellaver B, Zalzale H, Lussier FZ, Rohden F, Abbas S, Lemaire PC, Leffa DT, Cabrera A, Therriault J, Benedet AL, Tissot C, Wang YT, Chamoun M, Servaes S, Macedo AC, Vermeiren M, Bezgin G, Kang MS,...
Longitudinal blood biomarker trajectories in preclinical Alzheimer’s disease.
Yakoub Y, Ashton NJ, Strikwerda-Brown C, Montoliu-Gaya L, Karikari TK, Kac PR, Gonzalez-Ortiz F, Gallego-Rudolf J, Meyer PF, St-Onge F, Schöll M, Soucy JP, Breitner JCS, Zetterberg H, Blennow K, Poirier J, Villeneuve S; PREVENT-AD Research Group. Alzheimers Dement....
![4-3-3 [Formula: see text]-reported early synaptic injury in Alzheimer’s disease is independently mediated by sTREM2.](https://karikarilab.org/wp-content/uploads/2023/11/4-3-3-Formula-see-text-reported-early-synaptic-injury-in-Alzheimers-disease-is-independently-mediated-by-sTREM2-400x250.webp)
4-3-3 [Formula: see text]-reported early synaptic injury in Alzheimer’s disease is independently mediated by sTREM2.
Woo MS, Nilsson J, Therriault J, Rahmouni N, Brinkmalm A, Benedet AL, Ashton NJ, Macedo AC, Servaes S, Wang YT, Tissot C, Arias JF, Hosseini SA, Chamoun M, Lussier FZ, Karikari TK, Stevenson J, Mayer C, Ferrari-Souza JP, Kobayashi E, Massarweh G, Friese MA, Pascoal...
Brain-derived Tau for Monitoring Brain Injury in Acute Ischemic Stroke.
Vlegels N, Gonzalez-Ortiz F, Knuth NL, Khalifeh N, Gesierich B, Müller F, Müller P, Klein M, Dimitriadis K, Franzmeier N, Liebig T, Duering M, Reidler P, Dichgans M, Karikari TK, Blennow K, Tiedt S. medRxiv [Preprint]. 2023 Nov 19:2023.11.18.23298728. doi:...
Neuropsychiatric Symptoms and Microglial Activation in Patients with Alzheimer Disease.
Schaffer Aguzzoli C, Ferreira PCL, Povala G, Ferrari-Souza JP, Bellaver B, Soares Katz C, Zalzale H, Lussier FZ, Rohden F, Abbas S, Leffa DT, Scop Medeiros M, Therriault J, Benedet AL, Tissot C, Servaes S, Rahmouni N, Cassa Macedo A, Bezgin G, Kang MS, Stevenson J,...
Equivalence of plasma p-tau217 with cerebrospinal fluid in the diagnosis of Alzheimer’s disease.
Therriault J, Servaes S, Tissot C, Rahmouni N, Ashton NJ, Benedet AL, Karikari TK, Macedo AC, Lussier FZ, Stevenson J, Wang YT, Fernandez-Arias J, Stevenson A, Socualaya KQ, Haeger A, Nazneen T, Aumont É, Hosseini A, Rej S, Vitali P, Triana-Baltzer G, Kolb HC, Soucy...
Cross-sectional and longitudinal evaluation of plasma glial fibrillary acidic protein to detect and predict clinical syndromes of Alzheimer’s disease.
Ally M, Sugarman MA, Zetterberg H, Blennow K, Ashton NJ, Karikari TK, Aparicio HJ, Frank B, Tripodis Y, Martin B, Palmisano JN, Steinberg EG, Simkin I, Farrer LA, Jun GR, Turk KW, Budson AE, O'Connor MK, Au R, Goldstein LE, Kowall NW, Killiany R, Stern RA, Stein TD,...
A novel ultrasensitive assay for plasma p-tau217: performance in individuals with subjective cognitive decline and early Alzheimer’s disease.
Gonzalez-Ortiz F, Ferreira PCL, Gonzalez A, Montoliu-Gaya L, Ortiz-Romero P, Kac PR, Turton M, Kvartsberg H, Ashton NJ, Zetterberg H, Harrison P, Bellaver B, Povala G, Villemagne VL, Pascoal TA, Ganguli M, Cohen AD, Miguillon C, Contador J, Suarez-Calvet M, Karikari...
APOEε4 potentiates amyloid β effects on longitudinal tau pathology.
Ferrari-Souza JP, Bellaver B, Ferreira PCL, Benedet AL, Povala G, Lussier FZ, Leffa DT, Therriault J, Tissot C, Soares C, Wang YT, Chamoun M, Servaes S, Macedo AC, Vermeiren M, Bezgin G, Kang MS, Stevenson J, Rahmouni N, Pallen V, Poltronetti NM, Cohen A, Lopez OL,...
Plasma p-tau231 and p-tau217 inform on tau tangles aggregation in cognitively impaired individuals.
Ferreira PCL, Therriault J, Tissot C, Ferrari-Souza JP, Benedet AL, Povala G, Bellaver B, Leffa DT, Brum WS, Lussier FZ, Bezgin G, Servaes S, Vermeiren M, Macedo AC, Cabrera A, Stevenson J, Triana-Baltzer G, Kolb H, Rahmouni N, Klunk WE, Lopez OL, Villemagne VL, Cohen...
Preanalytical stability of plasma/serum brain-derived tau.
Gonzalez-Ortiz F, Dias A, Turton M, Magalhães R, Kac PR, Correia M, Harrison P, Zetterberg H, Maia LF, Blennow K, Karikari TK. Alzheimers Dement. 2023 Oct;19(10):4764-4770. doi: 10.1002/alz.13156. Epub 2023 May 26.
Longitudinal changes in Alzheimer’s-related plasma biomarkers and brain amyloid.
Bilgel M, An Y, Walker KA, Moghekar AR, Ashton NJ, Kac PR, Karikari TK, Blennow K, Zetterberg H, Jedynak BM, Thambisetty M, Ferrucci L, Resnick SM. Alzheimers Dement. 2023 Oct;19(10):4335-4345. doi: 10.1002/alz.13157. Epub 2023 May 22.
Plasma biomarkers identify older adults at risk of Alzheimer’s disease and related dementias in a real-world population-based cohort.
Ferreira PCL, Zhang Y, Snitz B, Chang CH, Bellaver B, Jacobsen E, Kamboh MI, Zetterberg H, Blennow K, Pascoal TA, Villemagne VL, Ganguli M, Karikari TK. Alzheimers Dement. 2023 Oct;19(10):4507-4519. doi: 10.1002/alz.12986. Epub 2023 Mar 6.
MEG3 activates necroptosis in human neuron xenografts modeling Alzheimer’s disease.
Balusu S, Horré K, Thrupp N, Craessaerts K, Snellinx A, Serneels L, T'Syen D, Chrysidou I, Arranz AM, Sierksma A, Simrén J, Karikari TK, Zetterberg H, Chen WT, Thal DR, Salta E, Fiers M, De Strooper B. Science. 2023 Sep 15;381(6663):1176-1182. doi:...
Blood-brain barrier integrity impacts the use of plasma amyloid-β as a proxy of brain amyloid-β pathology.
Bellaver B, Puig-Pijoan A, Ferrari-Souza JP, Leffa DT, Lussier FZ, Ferreira PCL, Tissot C, Povala G, Therriault J, Benedet AL, Ashton NJ, Servaes S, Chamoun M, Stevenson J, Rahmouni N, Vermeiren M, Macedo AC, Fernández-Lebrero A, García-Escobar G, Navalpotro-Gómez I,...
Revealing the combined roles of Aβ and tau in Alzheimer’s disease via a pathophysiological activity decoder.
Sanchez-Rodriguez LM, Bezgin G, Carbonell F, Therriault J, Fernandez-Arias J, Servaes S, Rahmouni N, Tissot C, Stevenson J, Karikari TK, Ashton NJ, Benedet AL, Zetterberg H, Blennow K, Triana-Baltzer G, Kolb HC, Rosa-Neto P, Iturria-Medina Y. bioRxiv [Preprint]. 2023...
Potential Utility of Plasma P-Tau and Neurofilament Light Chain as Surrogate Biomarkers for Preventive Clinical Trials.
Ferreira PCL, Ferrari-Souza JP, Tissot C, Bellaver B, Leffa DT, Lussier F, Povala G, Therriault J, Benedet AL, Ashton NJ, Cohen AD, Lopez OL, Tudorascu DL, Klunk WE, Soucy JP, Gauthier S, Villemagne V, Zetterberg H, Blennow K, Rosa-Neto P, Zimmer ER, Karikari TK,...
Association of Serum Brain-Derived Tau With Clinical Outcome and Longitudinal Change in Patients With Severe Traumatic Brain Injury.
Gonzalez-Ortiz F, Dulewicz M, Ashton NJ, Kac PR, Zetterberg H, Andersson E, Yakoub Y, Hanrieder J, Turton M, Harrison P, Nellgård B, Karikari TK, Blennow K. JAMA Netw Open. 2023 Jul 3;6(7):e2321554. doi: 10.1001/jamanetworkopen.2023.21554.