Publications
Cross-cohort validation and cutpoint estimation of the Janssen plasma p-tau217+ assay in predominantly cognitively normal community studies
Balogun WG, Zeng X, Triana-Baltzer G, Saeed A, Aigbogun HE, Gogola A, Lopresti BJ, Villemagne VL, Ganguli M, Kolb H, Snitz BE, Lopez OL, Cohen AD, Reis SE, Karikari TK. Cross-cohort validation and cutpoint estimation of the Janssen plasma p-tau217+ assay in...
Amyloid beta and tau are associated with the dual effect of neuroinflammation on neurodegeneration
Povala G, Bellaver B, Bastiani MA, Ferrari-Souza JP, Aguzzoli CS, Leffa DT, Ferreira PCL, Lussier FZ, Rocha A, Zalzale H, Soares C, Bauer-Negrini G, Therriault J, Rahmouni N, Stevenson J, Servaes S, Tissot C, Zatt B, Karikari TK, Ikonomovic MD, Villemagne VL, Gauthier...
Cohort profile: A community-based prospective cohort study of Alzheimer’s disease and related dementias in the Democratic Republic of Congo
Ikanga J, Obenauf C, Patel SS, Schwinne M, Gikelekele G, Epenge E, Potshi JM, Tomadia T, Kazadi J, Kavugho I, Santolini GL, Sabowa FM, Musewu BM, Mawisa E, Tsangu JP, Beya FMK, Mampunza S, Mananga L, Bukabau J, Teunissen CE, Karikari T, Gross AL, Rojas JC, Alonso A....
Associations of 18 F-RO-948 Tau PET with Fluid AD Biomarkers, Centiloid, and Cognition in the Early AD Continuum
Shekari M, González Escalante A, Milà-Alomà M, Falcon C, López-Martos D, Sánchez-Benavides G, Brugulat-Serrat A, Niñerola-Baizán A, Ashton NJ, Karikari TK, Lantero-Rodriguez J, Montoliu-Gaya L, Snellman A, Day TA, Dage JL, Ortiz-Romero P, Tonietto M, Borroni E, Klein...
Plasma biomarkers, brain amyloid pathology, and cortical thickness in a diverse middle-aged community cohort: the HCP-CoBRA study
Brodman ST, Heaton N, Triana-Baltzer G, Zeng X, Gogola A, Kamboh MI, Villemagne VL, Lopez OL, Kolb H, Deek RA, Cohen AD, Karikari TK. Plasma biomarkers, brain amyloid pathology, and cortical thickness in a diverse middle-aged community cohort: the HCP-CoBRA study....
Blood phosphorylated tau for the diagnosis of Alzheimer’s disease: a systematic review and meta-analysis
Therriault J, Brum WS, Trudel L, Macedo AC, Bitencourt FV, Martins-Pfeifer CC, Nakouzi M, Pola I, Wong M, Kac PR, Real AP, Witherow C, Karikari TK, Moscoso A, Zimmer ER, Schöll M, Pascoal T, Benedet AL, Ashton NJ, Schindler SE, Zetterberg H, Blennow K, Rosa-Neto P....
Diagnosis of Alzheimer’s disease using plasma biomarkers adjusted to clinical probability
Therriault J, Janelidze S, Benedet AL, Ashton NJ, Arranz Martínez J, Gonzalez-Escalante A, Bellaver B, Alcolea D, Vrillon A, Karim H, Mielke MM, Hyung Hong C, Roh HW, Contador J, Puig Pijoan A, Algeciras-Schimnich A, Vemuri P, Graff-Radford J, Lowe VJ, Karikari TK,...
Arterial stiffness moderates the link between NfL and cognition: The IGNITE study
Norling AM, Lipsitz LA, Dufour AB, Travison TG, Sewell KR, Collins AM, Wan L, Grove G, Huang H, Oberlin LE, Jain S, Karikari TK, Morris JK, Jakicic JM, McAuley E, Kramer AF, Hillman CH, Vidoni ED, Billinger SA, Burns JM, Marsland AL, Kang C, Erickson KI. Arterial...
Plasma brain-derived tau: analytical and clinical validation of the first commercial immunoassay
Nafash MN, Svirsky SE, Zeng X, Chen Y, Kofler J, Cohen AD, Okonkwo DO, Lopez OL, Puccio AM, Karikari TK. Plasma brain-derived tau: analytical and clinical validation of the first commercial immunoassay. medRxiv [Preprint]. 2025 Jul 21:2025.07.21.25331193. doi:...
Alzheimer’s Association Clinical Practice Guideline on the use of blood-based biomarkers in the diagnostic workup of suspected Alzheimer’s disease within specialized care settings
Palmqvist S, Whitson HE, Allen LA, Suarez-Calvet M, Galasko D, Karikari TK, Okrahvi HR, Paczynski M, Schindler SE, Teunissen CE, Zetterberg H, Carrillo MC, Edelmayer RM, Mahinrad S, McAteer MB, Kahale LA, Pahlke S, Tampi MP. Alzheimer's Association Clinical Practice...
Plasma biomarkers identify brain ATN abnormalities in a dementia-free population-based cohort
Dresse MT, Ferreira PCL, Prasadan A, Diaz JL, Zeng X, Bellaver B, Povala G, Villemagne VL, Kamboh MI, Cohen AD, Pascoal TA, Ganguli M, Snitz BE, Shaaban CE, Karikari TK. Plasma biomarkers identify brain ATN abnormalities in a dementia-free population-based cohort....
Pittsburgh plasma p-tau217: Classification accuracies for autosomal dominant and sporadic Alzheimer’s disease in the community
Sehrawat A, Zeng X, Abrahamson EE, Deek RA, Gogola A, Kamboh MI, Pascoal TA, Villemagne VL, Lopez OL, Ikonomovic MD, Snitz BE, Cohen AD, Karikari TK. Pittsburgh plasma p-tau217: Classification accuracies for autosomal dominant and sporadic Alzheimer's disease in the...
Impact of racialization on neuroimaging and plasma biomarkers of Alzheimer’s disease
Gogola A, Zeng X, Williams LA, Chapple-McGruder T, Saeed A, Lopresti BJ, Snitz B, Tudorascu D, Minhas D, Ikonomovic MD, Kofler J, Matan C, Pascoal TA, Aizenstein H, Zetterberg H, Blennow K, Lopez O, Villemagne VL, Karikari TK, Cohen AD. Impact of racialization on...
Glial reactivity correlates with synaptic dysfunction across aging and Alzheimer’s disease
Rohden F, Ferreira PCL, Bellaver B, Ferrari-Souza JP, Aguzzoli CS, Soares C, Abbas S, Zalzale H, Povala G, Lussier FZ, Leffa DT, Bauer-Negrini G, Rahmouni N, Tissot C, Therriault J, Servaes S, Stevenson J, Benedet AL, Ashton NJ, Karikari TK, Tudorascu DL, Zetterberg...
Utility of plasma GFAP as a secondary endpoint for clinical trials in Alzheimer’s disease
Abbas S, Ferreira PCL, Bellaver B, Povala G, Rohden F, Aguzzoli CS, Zalzale H, Ferrari-Souza JP, Leffa DT, Lussier FZ, Soares C, Bauer-Negrini G, Oliveira-Junior MS, Rodrigues MS, Saha P, Ruppert E, Medeiros MS, Tissot C, Therriault J, Rahmouni N, Servaes S, Benedet...
Equivalence of Plasma and Serum for Clinical Measurement of p-tau217: Comparative Analyses of Four Blood-Based Assays
Chen Y, Albert AL, Sehrawat A, Farinas M, Lopez OL, Zeng X, Cohen AD, Karikari TK. Equivalence of plasma and serum for clinical measurement of p-tau217: comparative analyses of four blood-based assays. medRxiv [Preprint]. 2024 Dec 28:2024.12.26.24319657. doi:...
Loneliness and Biomarkers of Alzheimer’s Disease, Axonal Damage, and Astrogliosis: A Coordinated Analysis of Two Longitudinal Cohorts
Terracciano A, Walker KA, An Y, Bilgel M, Sutin AR, Luchetti M, Karakose S, Stephan Y, Blennow K, Zetterberg H, Ashton NJ, Karikari TK, Kac PR, Moghekar AR, Thambisetty M, Ferrucci L, Resnick SM. Loneliness and Biomarkers of Alzheimer's Disease, Axonal Damage, and...
Blood biomarkers differentiate AD-related versus non-AD-related cognitive deficits
Sewell KR, Oberlin LE, Karikari TK, Olvera-Rojas M, Wan L, Morris JK, Kueck PJ, Zeng X, Huang H, Grove G, Chen Y, Lafferty TK, Sehrawat A, Kamboh MI, Marsland AL, Kramer AF, McAuley E, Burns JM, Hillman CH, Vidoni ED, Kang C, Erickson KI. Blood biomarkers...
Proteomic signatures of corona and herpes viral antibodies identify IGDCC4 as a mediator of neurodegeneration
Duggan MR, Yang S, Gomez GT, Cui Y, Capuano AW, Chen J, Yang Z, Wen J, Erus G, Drouin SM, Zweibaum D, Tian Q, Candia J, Bilgel M, Lewis A, Moghekar A, Ashton NJ, Kac PR, Karikari TK, Blennow K, Zetterberg H, Maher BS, Spira AP, Dumitrescu L, Hohman TJ, Gottesman RF,...
Plasma GFAP for populational enrichment of clinical trials in preclinical Alzheimer’s disease
Bellaver B, Povala G, Ferreira PCL, Bauer-Negrini G, Lussier FZ, Leffa DT, Ferrari-Souza JP, Rodrigues MS, Amaral L, Oliveira MS, Soares C, Rocha A, Saha P, Rahmouni N, Macedo A, Tissot C, Therriault J, Servaes S, Klostranec J, Montembeault M, Benedet AL, Ashton NJ,...
Dissection of blood–brain barrier dysfunction through CSF PDGFRβ and amyloid, tau, neuroinflammation, and synaptic CSF biomarkers in neurodegenerative disorders
Vrillon A, Ashton NJ, Bouaziz-Amar E, Mouton-Liger F, Cognat E, Dumurgier J, Lilamand M, Karikari TK, Prevot V, Zetterberg H, Blennow K, Paquet C. Dissection of blood-brain barrier dysfunction through CSF PDGFRβ and amyloid, tau, neuroinflammation, and synaptic CSF...
Sex differences on tau, astrocytic, and neurodegenerative plasma biomarkers
Labonte J, Sugarman MA, Pettway E, Zetterberg H, Blennow K, Ashton NJ, Karikari TK, Aparicio HJ, Frank B, Tripodis Y, Martin B, Palmisano JN, Steinberg EG, Simkin I, Farrer LA, Jun GR, Turk KW, Budson AE, O'Connor MK, Au R, Goldstein LE, Stern RA, Stein TD, McKee AC,...
Tau profiling across Alzheimer’s disease staging reveals vulnerability to disease pathophysiology
Bezgin G, Pascoal TA, Therriault J, Lussier FZ, Servaes S, Kang MS, Savard M, Tissot C, Stevenson J, Wang YT, Ottoy J, Rahmouni N, Fernandez-Arias J, Hosseini SA, Aumont É, Hall B, Poltronetti NM, Pallen V, Benedet AL, Ashton NJ, Blennow K, Zetterberg H, Karikari TK,...
Plasma p-tau212 as a biomarker of sporadic and Down syndrome Alzheimer’s disease
Kac PR, Alcolea D, Montoliu-Gaya L, Fernández S, Rodriguez JL, Maure L, González-Ortiz F, Benejam B, Turton M, Barroeta I, Harrison P, Videla L, Ashton NJ, Lleó A, Zetterberg H, Carmona-Iragui M, Karikari TK, Fortea J, Blennow K. Plasma p-tau212 as a biomarker of...
The LATTICE Study: Design of a pilot feasibility randomized controlled trial of lithium to delay cognitive decline in mild cognitive impairment
Gildengers AG, Ibrahim TS, Zeng X, Aizenstein HJ, Alkhateeb SK, Anderson SJ, Chu C, Diaz JL, Emanuel JE, Karikari TK, Li J, Lopez OL, Lopresti BJ, Royse SK, Sajewski AN, Santini T, Weinstein AM, Wu M, Butters MA. The LATTICE Study: Design of a pilot feasibility...
Utility of plasma GFAP as a secondary endpoint for clinical trials in Alzheimer’s disease
Abbas S, Ferreira PCL, Bellaver B, Povala G, Rohden F, Aguzzoli CS, Zalzale H, Ferrari-Souza JP, Leffa DT, Lussier FZ, Soares C, Bauer-Negrini G, Oliveira-Junior MS, Rodrigues MS, Saha P, Ruppert E, Medeiros MS, Tissot C, Therriault J, Rahmouni N, Servaes S, Benedet...
Phospho-tau serine-262 and serine-356 as biomarkers of pre-tangle soluble tau assemblies in Alzheimer’s disease
Islam T, Hill E, Abrahamson EE, Servaes S, Smirnov DS, Zeng X, Sehrawat A, Chen Y, Kac PR, Kvartsberg H, Olsson M, Sjons E, Gonzalez-Ortiz F, Therriault J, Tissot C, Del Popolo I, Rahmouni N, Richardson A, Mitchell V, Zetterberg H, Pascoal TA, Lashley T, Wall MJ,...