The Karikari Lab is situated at UPMC Western Psychiatric Hospitals, right in the heart of Pittsburgh’s healthcare corridor. Under the leadership of Thomas K. Karikari, Ph.D., a global expert in fluid biomarker assay development and validation, the lab is supported by a multidisciplinary team with a wide range of expertise. It encompasses ample laboratory space and advanced instrumentation to facilitate cutting-edge immunoassays and mass spectrometry experiments.
Our lab’s primary focus is advancing biomarker research for neurodegenerative diseases, including Alzheimer’s disease-related dementia (ADRD). We are particularly interested in developing and applying blood-based biomarker assays to detect toxic protein aggregates that contribute to neurodegenerative disorders. We have developed highly sensitive blood biomarkers for amyloid beta peptides and various forms of tau. In collaboration with clinical teams, we have applied these biomarkers to numerous clinical cohorts to evaluate their effectiveness in predicting AD pathologies. Our mission is to provide readily available tools for AD diagnosis and prognosis to a wide range of populations, including minoritized and low-income groups.
We welcome collaborative opportunities to further explore these advancements and extend their applications. Engaging with us offers a chance to contribute to transformative research and improve global healthcare outcomes. For collaboration inquiries and to learn more about our groundbreaking work, please contact us.
Recent Publications
Loneliness and Biomarkers of Alzheimer’s Disease, Axonal Damage, and Astrogliosis: A Coordinated Analysis of Two Longitudinal Cohorts
Terracciano A, Walker KA, An Y, Bilgel M, Sutin AR, Luchetti M, Karakose S, Stephan Y, Blennow K, Zetterberg H, Ashton NJ, Karikari TK, Kac PR, Moghekar AR, Thambisetty M, Ferrucci L, Resnick SM. Loneliness and Biomarkers of Alzheimer's Disease, Axonal Damage, and...
Blood biomarkers differentiate AD-related versus non-AD-related cognitive deficits
Sewell KR, Oberlin LE, Karikari TK, Olvera-Rojas M, Wan L, Morris JK, Kueck PJ, Zeng X, Huang H, Grove G, Chen Y, Lafferty TK, Sehrawat A, Kamboh MI, Marsland AL, Kramer AF, McAuley E, Burns JM, Hillman CH, Vidoni ED, Kang C, Erickson KI. Blood biomarkers...
Proteomic signatures of corona and herpes viral antibodies identify IGDCC4 as a mediator of neurodegeneration
Duggan MR, Yang S, Gomez GT, Cui Y, Capuano AW, Chen J, Yang Z, Wen J, Erus G, Drouin SM, Zweibaum D, Tian Q, Candia J, Bilgel M, Lewis A, Moghekar A, Ashton NJ, Kac PR, Karikari TK, Blennow K, Zetterberg H, Maher BS, Spira AP, Dumitrescu L, Hohman TJ, Gottesman RF,...
News
Funding and Affiliations




