{"id":56,"date":"2026-10-26T05:18:32","date_gmt":"2026-10-26T05:18:32","guid":{"rendered":"https:\/\/karikarilab.org\/?page_id=56"},"modified":"2026-10-27T06:11:00","modified_gmt":"2026-10-27T06:11:00","slug":"research","status":"publish","type":"page","link":"https:\/\/karikarilab.org\/?page_id=56","title":{"rendered":"Research"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"56\" class=\"elementor elementor-56\" data-elementor-post-type=\"page\">\n\t\t\t\t<div class=\"elementor-element elementor-element-7edec6f e-flex e-con-boxed e-con e-parent\" data-id=\"7edec6f\" data-element_type=\"container\" data-e-type=\"container\">\r\n\t\t\t\t\t<div class=\"e-con-inner\">\r\n\t\t\t\t<div class=\"elementor-element elementor-element-5acfb25 elementor-widget elementor-widget-html\" data-id=\"5acfb25\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t\t<!-- ============================================================\n  KARIKARI LAB \u2014 RESEARCH PAGE (body) \u2014 Elementor HTML widget\n  Place below the header widget (2-karikari-header.html).\n  Full-width: breaks out of boxed containers by itself.\n\n  HOW TO EDIT\n  \u2022 LAYOUT: on the root <div class=\"kl kl-research kl-layout-list\"> change\n      kl-layout-list  \u2192  kl-layout-cards   (image-card layout)\n  \u2022 LINKS: every href=\"#\" with a  LINK  note is a placeholder \u2014 paste your URL.\n  \u2022 IMAGES: every src with an  IMAGE  note \u2014 paste your Media Library URL.\n      (Images only show in the cards layout; they're skipped in the list layout.)\n  \u2022 ADD \/ REMOVE A PROJECT: copy one block between \u25bc PROJECT ITEM and\n      \u25b2 END PROJECT ITEM and paste it inside the same group. Delete a block to remove it.\n  \u2022 ADD \/ REMOVE A CATEGORY: copy\/delete a whole \u25bc CATEGORY block. Give it a\n      unique id, and add\/remove the matching pill in the hero nav.\n  \u2022 FUNDED PROJECTS: edit the PROJECTS list in the <script> at the bottom.\n      Counts, filters, dates and search update automatically.\n============================================================ -->\n<link rel=\"preconnect\" href=\"https:\/\/fonts.googleapis.com\">\n<link rel=\"preconnect\" href=\"https:\/\/fonts.gstatic.com\" crossorigin>\n<link href=\"https:\/\/fonts.googleapis.com\/css2?family=Archivo:wght@400;500;600;700;800;900&family=Spectral:ital,wght@0,300;0,400;0,500;0,600;1,400;1,500&display=swap\" rel=\"stylesheet\">\n<style>\n\n.kl, .kl *, .kl *::before, .kl *::after { box-sizing: border-box; }\n\/* Full-width breakout: escapes any Elementor boxed container \/ padding *\/\n.kl { background:#FFFFFF; color:#0C0D0F; font-family:'Archivo',Helvetica,Arial,sans-serif; -webkit-font-smoothing:antialiased; line-height:normal; position:relative; width:100vw; max-width:100vw; margin-left:calc(50% - 50vw); margin-right:calc(50% - 50vw); overflow-x:clip; }\n.elementor-widget-html, .elementor-widget-html .elementor-widget-container { max-width:none !important; }\nhtml, body { overflow-x:clip; }\nhtml { scroll-behavior:smooth; }\n@media (prefers-reduced-motion: reduce){ html { scroll-behavior:auto; } .kl *, .kl-fp-overlay * { transition:none !important; } }\n.kl h1,.kl h2,.kl h3,.kl p { margin:0; padding:0; }\n.kl a { text-decoration:none; transition:color .2s, background .2s, border-color .2s; }\n.kl img { max-width:none; }\n\n.kl .kl-wrap { max-width:1180px; margin:0 auto; }\n.kl .kl-eyebrow { display:flex; align-items:center; gap:14px; }\n.kl .kl-eyebrow .kl-bar { width:38px; height:3px; background:#F5DC0F; display:block; flex:none; }\n.kl .kl-eyebrow .kl-lbl { font-size:12px; font-weight:700; letter-spacing:0.22em; text-transform:uppercase; color:#5A5F66; }\n\n\/* ---------- Hero ---------- *\/\n.kl .kl-hero { position:relative; padding:clamp(64px,8vw,120px) clamp(20px,4vw,48px) clamp(64px,8vw,110px); background:radial-gradient(120% 90% at 78% 20%,#0E5C74 0%,#08334A 45%,#04121F 100%); color:#FFFFFF; }\n.kl .kl-hero .kl-eyebrow { margin-bottom:26px; }\n.kl .kl-hero .kl-eyebrow .kl-lbl { color:#B9E6EF; }\n.kl .kl-hero-title { margin:0 0 28px; max-width:16ch; font-family:'Spectral',Georgia,serif; font-size:clamp(42px,6vw,76px); line-height:1.02; font-weight:600; letter-spacing:-0.02em; text-wrap:balance; color:#FFFFFF; }\n.kl .kl-hero-lede { margin:0 0 40px; max-width:52ch; font-family:'Spectral',Georgia,serif; font-size:clamp(20px,2vw,25px); line-height:1.5; color:#D8DDE2; text-wrap:pretty; }\n.kl .kl-pills { display:flex; flex-wrap:wrap; gap:10px; }\n.kl .kl-pills a { padding:10px 18px; border:1px solid rgba(245,220,15,0.55); color:#F5DC0F; border-radius:999px; font-size:14px; font-weight:700; letter-spacing:0.02em; }\n.kl .kl-pills a:hover, .kl .kl-pills a:focus-visible { background:#F5DC0F; color:#0C0D0F; }\n\n\/* ---------- Programmes (shared) ---------- *\/\n.kl .kl-programs { padding:clamp(64px,8vw,110px) clamp(20px,4vw,48px); }\n.kl .kl-programs > .kl-wrap { display:flex; flex-direction:column; gap:clamp(64px,8vw,100px); }\n.kl .kl-cat { scroll-margin-top:120px; }\n.kl .kl-cat-head .kl-eyebrow { margin-bottom:14px; }\n.kl .kl-cat-title { margin:0 0 14px; font-family:'Spectral',Georgia,serif; font-size:clamp(30px,3.2vw,40px); line-height:1.1; font-weight:600; letter-spacing:-0.015em; color:#0C0D0F; }\n.kl .kl-cat-desc { margin:0; font-size:17px; line-height:1.6; color:#5A5F66; max-width:36ch; text-wrap:pretty; }\n.kl .kl-items { min-width:0; }\n.kl .kl-proj { color:#0C0D0F; }\n.kl .kl-proj-title { font-family:'Spectral',Georgia,serif; font-weight:600; letter-spacing:-0.01em; text-wrap:balance; }\n\n\/* ---------- LIST layout ---------- *\/\n.kl.kl-layout-list .kl-cat { display:grid; grid-template-columns:minmax(0,1fr); gap:24px clamp(40px,6vw,96px); align-items:start; }\n@media (min-width:1130px){ .kl.kl-layout-list .kl-cat { grid-template-columns:minmax(0,1fr) minmax(0,2fr); } }\n.kl.kl-layout-list .kl-items { display:flex; 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text-transform:uppercase; color:#1663CF; }\n.kl.kl-layout-cards .kl-proj-arrow { display:none; }\n\n\/* ---------- Funded research ---------- *\/\n.kl .kl-funded { background:#F4F3EF; border-top:1px solid #E7E5DE; padding:clamp(56px,7vw,96px) clamp(20px,4vw,48px); }\n.kl .kl-funded > .kl-wrap { display:grid; grid-template-columns:repeat(auto-fit,minmax(min(100%,340px),1fr)); gap:32px clamp(40px,6vw,96px); align-items:end; }\n.kl .kl-funded .kl-eyebrow { margin-bottom:18px; }\n.kl .kl-funded-title { margin:0 0 16px; font-family:'Spectral',Georgia,serif; font-size:clamp(32px,3.6vw,46px); line-height:1.08; font-weight:600; letter-spacing:-0.015em; color:#0C0D0F; }\n.kl .kl-funded-desc { margin:0; font-size:18px; line-height:1.6; color:#3C3F45; max-width:48ch; text-wrap:pretty; }\n.kl .kl-funded-side { display:flex; flex-direction:column; gap:22px; align-items:flex-start; }\n.kl .kl-sum-chips { display:flex; flex-wrap:wrap; gap:8px; }\n.kl .kl-sum-chip { display:flex; align-items:baseline; gap:8px; padding:8px 14px; background:#FFFFFF; border:1px solid #E7E5DE; border-radius:999px; font-size:14px; font-weight:700; color:#0C0D0F; }\n.kl .kl-sum-chip .kl-n { font-weight:500; color:#5A5F66; }\n.kl .kl-btn-dark, .kl .kl-btn-dark:focus { display:flex; align-items:center; gap:12px; padding:16px 26px; background:#0C0D0F; color:#FFFFFF; border:0; border-radius:999px; font-family:'Archivo',Helvetica,Arial,sans-serif; font-size:15px; font-weight:700; letter-spacing:0.02em; line-height:normal; text-transform:none; box-shadow:none; cursor:pointer; transition:background .2s; }\n.kl .kl-btn-dark:hover, .kl .kl-btn-dark:focus-visible { background:#1663CF; color:#FFFFFF; }\n.kl .kl-btn-dark .kl-arr { color:#F5DC0F; }\n\n\/* ---------- Footer ---------- *\/\n.kl .kl-footer { background:#0C0D0F; color:#9AA0A8; padding:clamp(40px,5vw,56px) clamp(20px,4vw,48px); display:flex; justify-content:space-between; align-items:center; gap:32px; flex-wrap:wrap; font-size:14px; border-top:1px solid #232529; 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letter-spacing:0.1em; text-transform:uppercase; color:#1663CF; }\n.kl-fp-overlay .kl-fp-ptitle { font-family:'Spectral',Georgia,serif; font-size:20px; line-height:1.3; font-weight:600; text-wrap:pretty; }\n.kl-fp-overlay .kl-fp-line { font-size:14px; line-height:1.5; color:#5A5F66; }\n.kl-fp-overlay .kl-fp-icon { width:32px; height:32px; border:1px solid #C9CBC4; border-radius:999px; display:flex; align-items:center; justify-content:center; font-size:18px; color:#0C0D0F; }\n.kl-fp-overlay .kl-fp-detail { padding:0 52px 24px 0; }\n.kl-fp-overlay .kl-fp-detail[hidden] { display:none; }\n.kl-fp-overlay .kl-fp-dlabel { font-size:12px; font-weight:700; letter-spacing:0.16em; text-transform:uppercase; color:#5A5F66; margin-bottom:8px; }\n.kl-fp-overlay .kl-fp-obj { margin:0; font-size:16px; line-height:1.65; color:#3C3F45; text-wrap:pretty; }\n.kl-fp-overlay .kl-fp-empty { margin:40px 0; font-size:16px; color:#5A5F66; }\n.kl-fp-overlay :focus-visible, .kl :focus-visible { outline:2px solid #1663CF; outline-offset:2px; }\n@media (max-width:600px){ .kl-fp-overlay .kl-fp-detail { padding-right:0; } }\n\n<\/style>\n\n<!-- Root: change kl-layout-list \u2192 kl-layout-cards to switch layout -->\n<div class=\"kl kl-research kl-layout-list\">\n\n  <!-- ================= HERO ================= -->\n  <section class=\"kl-hero\">\n    <div class=\"kl-wrap\">\n      <div class=\"kl-eyebrow\"><span class=\"kl-bar\"><\/span><span class=\"kl-lbl\">Research<\/span><\/div>\n      <h1 class=\"kl-hero-title\">Understanding the biology, and how it shows in blood<\/h1>\n      <p class=\"kl-hero-lede\">We study the biological processes that drive Alzheimer's disease and other dementias, and develop assays that measure how that biology is reflected in blood. Each project brings us closer to diagnosis, monitoring and care based on biology.<\/p>\n\n      <!-- Category jump links (delete this <nav> to hide). Each href must match a category id below. -->\n      <nav class=\"kl-pills\" aria-label=\"Research areas\">\n        <a href=\"#new-assays\">New assay formats<\/a>\n        <a href=\"#access\">Increase of access<\/a>\n        <a href=\"#clinical\">Clinical implementation<\/a>\n      <\/nav>\n    <\/div>\n  <\/section>\n\n  <!-- ================= PROGRAMMES ================= -->\n  <section class=\"kl-programs\">\n    <div class=\"kl-wrap\">\n\n      <!-- \u25bc CATEGORY 01 \u25bc -->\n      <div class=\"kl-cat\" id=\"new-assays\">\n        <div class=\"kl-cat-head\">\n          <div>\n            <div class=\"kl-eyebrow\"><span class=\"kl-bar\"><\/span><span class=\"kl-lbl\">01<\/span><\/div>\n            <h2 class=\"kl-cat-title\">New assay formats<\/h2>\n          <\/div>\n          <p class=\"kl-cat-desc\">Next-generation blood tests that capture more of the biology behind neurodegeneration.<\/p>\n        <\/div>\n        <div class=\"kl-items\">\n\n          <!-- \u25bc PROJECT ITEM \u25bc -->\n          <a class=\"kl-proj\" href=\"https:\/\/karikarilab.org\/?page_id=226\"><!-- LINK: project page URL -->\n            <div class=\"kl-proj-media\"><img decoding=\"async\" src=\"https:\/\/images.pexels.com\/photos\/3825527\/pexels-photo-3825527.jpeg?auto=compress&amp;cs=tinysrgb&amp;w=900\" alt=\"A scientist holding a molecular model\" loading=\"lazy\"><!-- IMAGE --><\/div>\n            <span class=\"kl-proj-text\">\n              <span class=\"kl-proj-title\">Unlocking tau heterogeneity through post-translational modification biomarkers in plasma<\/span>\n              <span class=\"kl-proj-more\">Read project \u2192<\/span>\n            <\/span>\n            <span class=\"kl-proj-arrow\" aria-hidden=\"true\">\u2192<\/span>\n          <\/a>\n          <!-- \u25b2 END PROJECT ITEM \u25b2 -->\n\n          <!-- \u25bc PROJECT ITEM \u25bc -->\n          <a class=\"kl-proj\" href=\"https:\/\/karikarilab.org\/?page_id=235\"><!-- LINK -->\n            <div class=\"kl-proj-media\"><img decoding=\"async\" src=\"https:\/\/images.pexels.com\/photos\/17485658\/pexels-photo-17485658.png?auto=compress&amp;cs=tinysrgb&amp;w=900\" alt=\"Abstract flowing glass-like structure in blue\" loading=\"lazy\"><!-- IMAGE --><\/div>\n            <span class=\"kl-proj-text\">\n              <span class=\"kl-proj-title\">Tracking the emergence of tau aggregation<\/span>\n              <span class=\"kl-proj-more\">Read project \u2192<\/span>\n            <\/span>\n            <span class=\"kl-proj-arrow\" aria-hidden=\"true\">\u2192<\/span>\n          <\/a>\n          <!-- \u25b2 END PROJECT ITEM \u25b2 -->\n\n          <!-- \u25bc PROJECT ITEM \u25bc -->\n          <a class=\"kl-proj\" href=\"https:\/\/karikarilab.org\/?page_id=243\"><!-- LINK -->\n            <div class=\"kl-proj-media\"><img decoding=\"async\" src=\"https:\/\/images.pexels.com\/photos\/4226119\/pexels-photo-4226119.jpeg?auto=compress&amp;cs=tinysrgb&amp;w=900\" alt=\"A hand pointing at brain scans on a light board\" loading=\"lazy\"><!-- IMAGE --><\/div>\n            <span class=\"kl-proj-text\">\n              <span class=\"kl-proj-title\">Tracing the origins of tau in blood<\/span>\n              <span class=\"kl-proj-more\">Read project \u2192<\/span>\n            <\/span>\n            <span class=\"kl-proj-arrow\" aria-hidden=\"true\">\u2192<\/span>\n          <\/a>\n          <!-- \u25b2 END PROJECT ITEM \u25b2 -->\n\n          <!-- \u25bc PROJECT ITEM \u25bc -->\n          <a class=\"kl-proj\" href=\"https:\/\/karikarilab.org\/?page_id=251\"><!-- LINK -->\n            <div class=\"kl-proj-media\"><img decoding=\"async\" src=\"https:\/\/images.pexels.com\/photos\/5726706\/pexels-photo-5726706.jpeg?auto=compress&amp;cs=tinysrgb&amp;w=900\" alt=\"A scientist in safety glasses working at a microscope\" loading=\"lazy\"><!-- IMAGE --><\/div>\n            <span class=\"kl-proj-text\">\n              <span class=\"kl-proj-title\">Biomarkers for mixed neurodegenerative pathologies<\/span>\n              <span class=\"kl-proj-more\">Read project \u2192<\/span>\n            <\/span>\n            <span class=\"kl-proj-arrow\" aria-hidden=\"true\">\u2192<\/span>\n          <\/a>\n          <!-- \u25b2 END PROJECT ITEM \u25b2 -->\n\n        <\/div>\n      <\/div>\n      <!-- \u25b2 END CATEGORY 01 \u25b2 -->\n\n      <!-- \u25bc CATEGORY 02 \u25bc -->\n      <div class=\"kl-cat\" id=\"access\">\n        <div class=\"kl-cat-head\">\n          <div>\n            <div class=\"kl-eyebrow\"><span class=\"kl-bar\"><\/span><span class=\"kl-lbl\">02<\/span><\/div>\n            <h2 class=\"kl-cat-title\">Increase of access<\/h2>\n          <\/div>\n          <p class=\"kl-cat-desc\">Taking biomarker testing beyond the clinic, to the people who need it most.<\/p>\n        <\/div>\n        <div class=\"kl-items\">\n\n          <!-- \u25bc PROJECT ITEM \u25bc -->\n          <a class=\"kl-proj\" href=\"https:\/\/karikarilab.org\/?page_id=259\"><!-- LINK -->\n            <div class=\"kl-proj-media\"><img decoding=\"async\" src=\"https:\/\/images.pexels.com\/photos\/8624589\/pexels-photo-8624589.jpeg?auto=compress&amp;cs=tinysrgb&amp;w=900\" alt=\"An older woman at home, looking out of a sunlit window\" loading=\"lazy\"><!-- IMAGE --><\/div>\n            <span class=\"kl-proj-text\">\n              <span class=\"kl-proj-title\">Bringing Alzheimer's blood testing to people, wherever they are<\/span>\n              <span class=\"kl-proj-more\">Read project \u2192<\/span>\n            <\/span>\n            <span class=\"kl-proj-arrow\" aria-hidden=\"true\">\u2192<\/span>\n          <\/a>\n          <!-- \u25b2 END PROJECT ITEM \u25b2 -->\n\n        <\/div>\n      <\/div>\n      <!-- \u25b2 END CATEGORY 02 \u25b2 -->\n\n      <!-- \u25bc CATEGORY 03 \u25bc -->\n      <div class=\"kl-cat\" id=\"clinical\">\n        <div class=\"kl-cat-head\">\n          <div>\n            <div class=\"kl-eyebrow\"><span class=\"kl-bar\"><\/span><span class=\"kl-lbl\">03<\/span><\/div>\n            <h2 class=\"kl-cat-title\">Clinical implementation<\/h2>\n          <\/div>\n          <p class=\"kl-cat-desc\">Turning biomarker results into decisions clinicians can act on.<\/p>\n        <\/div>\n        <div class=\"kl-items\">\n\n          <!-- \u25bc PROJECT ITEM \u25bc -->\n          <a class=\"kl-proj\" href=\"https:\/\/karikarilab.org\/?page_id=267\"><!-- LINK -->\n            <div class=\"kl-proj-media\"><img decoding=\"async\" src=\"https:\/\/images.pexels.com\/photos\/2280549\/pexels-photo-2280549.jpeg?auto=compress&amp;cs=tinysrgb&amp;w=900\" alt=\"A row of identical laboratory tubes filled with blue liquid\" loading=\"lazy\"><!-- IMAGE --><\/div>\n            <span class=\"kl-proj-text\">\n              <span class=\"kl-proj-title\">One scale for every p-tau217 blood test<\/span>\n              <span class=\"kl-proj-more\">Read project \u2192<\/span>\n            <\/span>\n            <span class=\"kl-proj-arrow\" aria-hidden=\"true\">\u2192<\/span>\n          <\/a>\n          <!-- \u25b2 END PROJECT ITEM \u25b2 -->\n\n          <!-- \u25bc PROJECT ITEM \u25bc -->\n          <a class=\"kl-proj\" href=\"https:\/\/karikarilab.org\/?page_id=278\"><!-- LINK -->\n            <div class=\"kl-proj-media\"><img decoding=\"async\" src=\"https:\/\/images.pexels.com\/photos\/6285362\/pexels-photo-6285362.jpeg?auto=compress&amp;cs=tinysrgb&amp;w=900\" alt=\"Two clinicians reviewing data together on a computer screen\" loading=\"lazy\"><!-- IMAGE --><\/div>\n            <span class=\"kl-proj-text\">\n              <span class=\"kl-proj-title\">Turning biomarker data into clinical insight<\/span>\n              <span class=\"kl-proj-more\">Read project \u2192<\/span>\n            <\/span>\n            <span class=\"kl-proj-arrow\" aria-hidden=\"true\">\u2192<\/span>\n          <\/a>\n          <!-- \u25b2 END PROJECT ITEM \u25b2 -->\n\n        <\/div>\n      <\/div>\n      <!-- \u25b2 END CATEGORY 03 \u25b2 -->\n\n    <\/div>\n  <\/section>\n\n  <!-- ================= FUNDED RESEARCH (delete this section + the panel below to hide) ================= -->\n  <section class=\"kl-funded\" id=\"funded-projects\">\n    <div class=\"kl-wrap\">\n      <div>\n        <div class=\"kl-eyebrow\"><span class=\"kl-bar\"><\/span><span class=\"kl-lbl\">Funded research<\/span><\/div>\n        <h2 class=\"kl-funded-title\" data-kl=\"fp-total\">Active funded projects<\/h2>\n        <p class=\"kl-funded-desc\">Alongside the programmes above, the lab leads and contributes blood biomarker work to studies funded by the NIH, the U.S. Department of Defense and private foundations, with collaborators across the country.<\/p>\n      <\/div>\n      <div class=\"kl-funded-side\">\n        <div class=\"kl-sum-chips\" data-kl=\"fp-summary\"><\/div>\n        <button type=\"button\" class=\"kl-btn-dark\" data-kl=\"fp-open\" aria-haspopup=\"dialog\">View all funded projects <span class=\"kl-arr\" aria-hidden=\"true\">\u2192<\/span><\/button>\n      <\/div>\n    <\/div>\n  <\/section>\n\n  <!-- Slide-over panel (filled by the script) -->\n  <div class=\"kl-fp-overlay\" data-kl=\"fp-overlay\" hidden>\n    <div class=\"kl-fp-backdrop\" data-kl=\"fp-close\"><\/div>\n    <aside class=\"kl-fp-panel\" role=\"dialog\" aria-modal=\"true\" aria-labelledby=\"kl-fp-heading\">\n      <div class=\"kl-fp-head\">\n        <div class=\"kl-fp-top\">\n          <div>\n            <div class=\"kl-fp-kicker\">Funded research<\/div>\n            <h2 class=\"kl-fp-title\" id=\"kl-fp-heading\">Active funded projects<\/h2>\n          <\/div>\n          <button type=\"button\" class=\"kl-fp-close\" data-kl=\"fp-close\" aria-label=\"Close\">\u00d7<\/button>\n        <\/div>\n        <input type=\"search\" class=\"kl-fp-search\" data-kl=\"fp-search\" placeholder=\"Search by title, objective, award number or institution\" aria-label=\"Search funded projects\">\n        <div class=\"kl-fp-filters\" data-kl=\"fp-filters\" role=\"group\" aria-label=\"Filter by funder\"><\/div>\n        <div class=\"kl-fp-count\" data-kl=\"fp-count\" aria-live=\"polite\"><\/div>\n      <\/div>\n      <div class=\"kl-fp-body\" data-kl=\"fp-list\"><\/div>\n    <\/aside>\n  <\/div>\n<\/div>\n\n<script>\n(function () {\n  \/* ============================================================\n     >>> EDIT THIS: settings <<<\n     sort: 'newest' (newest start first) | 'ending' (ending soonest) | 'funder' (A\u2013Z)\n     groups: filter buttons, in order. Each project's \"group\" must match one of these.\n  ============================================================ *\/\n  var CONFIG = {\n    sort: 'newest',\n    groups: ['NIA', 'NINDS', 'NIMH', 'DoD', 'Foundations']\n  };\n\n  \/* ============================================================\n     >>> EDIT THIS: funded projects <<<\n     To ADD: copy one { ... }, block (including the trailing comma) and edit it.\n     To REMOVE: delete its { ... }, block.\n     Fields:\n       title  \u2013 project title\n       funder \u2013 full funder name\n       group  \u2013 NIA | NINDS | NIMH | DoD | Foundations (see CONFIG.groups)\n       award  \u2013 award number (\"\" if none)\n       place  \u2013 lead institution (\"\" if led at Pitt)\n       start \/ end \u2013 MM\/YYYY  (the date line is generated automatically)\n       obj    \u2013 objectives text\n  ============================================================ *\/\n  var PROJECTS = [\n    { title: \"Preserving Cognitive Resilience: A Midlife Parent Offspring Study\", funder: \"National Institute on Aging (NIH)\", group: \"NIA\", award: \"5 R01 AG058679-06\", place: \"Rush University Medical Center\", start: \"12\/2025\", end: \"05\/2026\",\n      obj: \"To test if higher parental cognitive resilience is associated with less MRI evidence of white matter, hippocampal, and cortical gray matter injury in the offspring, and to test if these associations are different by race\/ethnicity and gender groups.\" },\n    { title: \"Targeting Inflammation in Cardiovascular Disease and Dementia\", funder: \"Greater Houston Community Foundation\", group: \"Foundations\", award: \"\", place: \"\", start: \"12\/2025\", end: \"11\/2026\",\n      obj: \"To encompass basic science discovery through clinical and genetic information as well as computational analysis.\" },\n    { title: \"Cognitive SuperAging: A Model to Explore Resilience and Resistance to Aging and Alzheimer\u2019s Disease\", funder: \"National Institute on Aging (NIH)\", group: \"NIA\", award: \"5 U19 AG073153-06\", place: \"University of Chicago\", start: \"09\/2025\", end: \"08\/2026\",\n      obj: \"To establish a multicenter SuperAging Consortium to identify behavioral, health, biologic, genetic, environmental, socioeconomic, psychosocial, anatomic and neuropathologic factors associated with SuperAging.\" },\n    { title: \"Developing a NAMPT Activator for Alzheimer's Disease\", funder: \"National Institute on Aging (NIH)\", group: \"NIA\", award: \"5 U01 AG079828-03\", place: \"\", start: \"09\/2025\", end: \"08\/2028\",\n      obj: \"To advance a brain penetrant, small molecule that augments NAMPT activity, thus increasing neuronal NAD+ levels and combating brain aging.\" },\n    { title: \"Multimodal in Vivo and Postmortem Analysis of ARIA-Relevant Pathophysiology\", funder: \"National Institute of Neurological Disorders and Stroke (NIH)\", group: \"NINDS\", award: \"1 U24 NS141780-01\", place: \"\", start: \"08\/2025\", end: \"07\/2030\",\n      obj: \"Passive immunotherapy with anti-amyloid-\u00df (A\u00df) antibodies has emerged as the first FDA-approved disease-modifying approach for Alzheimer\u2019s disease (AD). Treatment benefits come at the cost of clinical and radiological side effects. Human autopsy studies are critically needed for further neuropathological characterization, confirmation of disease mechanisms, and to inform development of novel biomarkers and preventive strategies. We are proposing a multi-pronged approach to bridge the gap between ante-mortem neuroimaging and fluid biomarker evaluations to autopsy studies by combining traditional neuropathology approaches with modern digital pathology techniques and MRI-guided tissue sampling.\" },\n    { title: \"Advancing Alzheimer\u2019s Disease Risk Profiling in Midlife Women: Leveraging Menopause-Related Risk Factors\", funder: \"Wellcome Leap\", group: \"Foundations\", award: \"CARE-2025-7270262472\", place: \"\", start: \"07\/2025\", end: \"06\/2028\",\n      obj: \"To leverage our extensive menopause-related data, novel AD biomarkers, and state-of-the-art AI- driven models to identify women at midlife who are at greatest risk for AD as they age.\" },\n    { title: \"Alzheimer's Disease Research Centers (Core G: Biomarker & Genetics)\", funder: \"National Institute on Aging (NIH)\", group: \"NIA\", award: \"2 P30 AG066468-06\", place: \"\", start: \"06\/2025\", end: \"02\/2030\",\n      obj: \"To oversee clinical assessment and care, stimulate dementia research, and train health professionals in Alzheimer\u2019s disease and other dementias.\" },\n    { title: \"Patients with Repetitive Brain Impact (RHI) Orally Supplemented with Gammaglutamylcysteine: An Open Label Trial with MR Spectroscopy and Neuropsychological Testing\", funder: \"Chuck Noll Foundation for Brain Injury Research\", group: \"Foundations\", award: \"\", place: \"\", start: \"01\/2025\", end: \"12\/2026\",\n      obj: \"To complete glutathione and iron assays as blood-based biomarker measures of intervention effects\" },\n    { title: \"Brain CHEC-AC (Brain and Cognitive Health Equity Campaign for Allegheny County)\", funder: \"National Institute of Neurological Disorders and Stroke (NIH)\", group: \"NINDS\", award: \"5 U01 NS141777-02\", place: \"\", start: \"09\/2024\", end: \"08\/2029\",\n      obj: \"To engage adults who are directly impacted by late-life cognitive health with brain health narrative campaign materials for deployment over multimedia platforms, 2) deploy a community-focused brain health narrative campaign around brain health disorders in the places where adults at risk for ADRD live, work, shop, and play, and 3) to assess the feasibility and acceptability of bringing state of the science AD blood-based biomarker testing to the places where individuals at highest risk live, work, shop, and play.\" },\n    { title: \"Brain Risk Assessment for Individual Neurological (BRAIN) Health: Understanding\/Preventing Consequences from Repetitive mTBI and Head Impact Exposures (Projects 1\u20134)\", funder: \"U.S. Department of Defense\", group: \"DoD\", award: \"HT94252320064\", place: \"\", start: \"09\/2024\", end: \"09\/2027\",\n      obj: \"To evaluate the effects of repetitive mTBI on BRAIN Health using a quantitative, multidomain clinical and blood-based biomarker assessment.\" },\n    { title: \"Analytical Characterization and Validation of Blood-biomarkers for Monitoring TBI Evolution\", funder: \"National Institute of Neurological Disorders and Stroke (NIH)\", group: \"NINDS\", award: \"5 U01 NS131740-02\", place: \"\", start: \"08\/2024\", end: \"07\/2028\",\n      obj: \"To conduct analytical validation of 7 promising neurotrauma biomarkers to prepare for adoption and practical use in multi-institutional clinical studies of acute and subacute TBI, with rapid, reliable results.\" },\n    { title: \"Neural Mechanisms of Anticholinergic Burden in Mid- to Late-Life Schizophrenia Spectrum Illness\", funder: \"National Institute of Mental Health (NIH)\", group: \"NIMH\", award: \"5 R01 MH135096-02\", place: \"\", start: \"08\/2024\", end: \"07\/2029\",\n      obj: \"To conduct a prospective study of the molecular and functional impacts of anticholinergic reduction via deprescription in mid- to late-life patients with SSD.\" },\n    { title: \"Alzheimer\u2019s Diagnosis in Older Adults with Chronic Conditions (ADACC) Network\", funder: \"National Institute on Aging (NIH)\", group: \"NIA\", award: \"5 U24 AG082930-03\", place: \"Wake Forest University\", start: \"09\/2023\", end: \"05\/2028\",\n      obj: \"To establish a national consortium, ADACC Network, consisting of multidisciplinary investigators that will develop evidence-backed strategies for the use and implementation of biomarkers for ADRD diagnosis of older patients with MCC and CI.\" },\n    { title: \"Examining the Persistence of Neurocognitive Benefits of Exercise\", funder: \"National Institute on Aging (NIH)\", group: \"NIA\", award: \"5 R01 AG083156-03\", place: \"AdventHealth\", start: \"09\/2023\", end: \"05\/2028\",\n      obj: \"To test the effects of the IGNITE exercise RCT on cognitive performance 5-years after the completion of the intervention, and to examine the extent to which participants maintained exercise behaviors 5- years after the completion of the intervention.\" },\n    { title: \"Plasma Brain-derived Tau: A Novel Alzheimer\u2019s Disease-Type Neurodegeneration Biomarker with Potential to Complete the AT(N) Scheme in Blood\", funder: \"National Institute on Aging (NIH)\", group: \"NIA\", award: \"5 R01 AG083874-03\", place: \"\", start: \"09\/2023\", end: \"05\/2028\",\n      obj: \"To compare associations of plasma BD-tau, NfL and t-tau with clinical diagnosis of AD and cognitive performance.\" },\n    { title: \"In Vivo Assessment of Neuroimmune Response to AD Pathology and Neurodegeneration\", funder: \"Aging Mind Foundation\", group: \"Foundations\", award: \"DAF2255207\", place: \"\", start: \"09\/2022\", end: \"12\/2026\",\n      obj: \"To combine imaging and fluid biomarkers of astrogliosis, AD pathology, cerebrovascular disease, and markers of neurodegeneration for the development of new therapies.\" },\n    { title: \"Myosteatosis, Cognition, and Blood Biomarkers of Alzheimer\u2019s Disease in Persons of African Ancestry\", funder: \"National Institute on Aging (NIH)\", group: \"NIA\", award: \"3 RF1 AG077474-01S1\", place: \"\", start: \"08\/2022\", end: \"03\/2026\",\n      obj: \"To include data on younger men and women, aged 45-65, in a study of blood levels of Alzheimer\u2019s Disease (AD) biomarkers as they relate to muscle adiposity.\" },\n    { title: \"The RAW Brain - The Effect of Rumination, Anxiety and Worry on Aging and Dementia Risk\", funder: \"National Institute of Mental Health (NIH)\", group: \"NIMH\", award: \"5 R01 MH108509-09\", place: \"\", start: \"08\/2022\", end: \"06\/2027\",\n      obj: \"To identify the pathways through which the RAW phenotypes contribute to accelerated aging and increased ADRD risk.\" },\n    { title: \"The Role of Astrogliosis in Aging and the Pathological and Clinical Progression of Alzheimer's Disease (Fluid Biomarker Core)\", funder: \"National Institute on Aging (NIH)\", group: \"NIA\", award: \"5 P01 AG025204-18\", place: \"\", start: \"08\/2022\", end: \"04\/2028\",\n      obj: \"To provide quality-controlled results of blood biomarkers in a format that can be easily used by projects for the analyzes associated with their aims.\" },\n    { title: \"Head-to-head Comparisons of High-performance Plasma Phospho-tau Epitopes for the Detection of Alzheimer's Disease\", funder: \"National Institute on Aging (NIH)\", group: \"NIA\", award: \"5 R01 AG075336-04\", place: \"\", start: \"03\/2022\", end: \"02\/2027\",\n      obj: \"To compare the performance of plasma p-tau epitopes to identify early and late depositions of Ab and tau proteins measured by PET.\" },\n    { title: \"Predictors of Altered CNS Structure, Function, and Connectomics in the Elderly using a Health Disparities Framework\", funder: \"National Institute on Aging (NIH)\", group: \"NIA\", award: \"5 R01 AG072641-03\", place: \"\", start: \"02\/2022\", end: \"11\/2027\",\n      obj: \"To investigate health and environmental risk factors in the natural history of Alzheimer\u2019s Disease.\" },\n    { title: \"Longitudinal Multicenter Head-to-head Harmonization of Tau PET Tracers\", funder: \"National Institute on Aging (NIH)\", group: \"NIA\", award: \"5 R01 AG073267-05\", place: \"\", start: \"09\/2021\", end: \"05\/2026\",\n      obj: \"To compare cross-sectional and longitudinal tau measures obtained with the two most widely used tau PET tracers, [18F]Flortaucipir and [18F]MK6240, head-to-head in the same volunteers.\" },\n    { title: \"Mild Cognitive Impairment: A Prospective Community Study\", funder: \"National Institute on Aging (NIH)\", group: \"NIA\", award: \"5 R37 AG023651-20\", place: \"\", start: \"05\/2021\", end: \"02\/2027\",\n      obj: \"To identify, at the population level, risk factors for clinically relevant adverse cognitive outcomes of MCI, cognitive decline, and progression to dementia.\" },\n    { title: \"Roles of Gray Matter Brain Aging and Small Vessel Disease in AD Pathophysiology\", funder: \"National Institute on Aging (NIH)\", group: \"NIA\", award: \"5 R01 AG025516-14\", place: \"\", start: \"03\/2021\", end: \"02\/2026\",\n      obj: \"To study the atrophy-related components of aging and 7T vascular imaging to characterize the SVD components of aging.\" },\n    { title: \"2\/3: Recurrence Markers, Cognitive Burden and Neurobiological Homeostasis in Late-life Depression (REMBRANDT)\", funder: \"National Institute of Mental Health (NIH)\", group: \"NIMH\", award: \"5 R01 MH121619-05\", place: \"\", start: \"01\/2020\", end: \"03\/2026\",\n      obj: \"To identify neurobiological factors that predict recurrence risk, and examine how cognitive performance changes are both influenced by these same neurobiological factors and also predict recurrence risk.\" }\n  ];\n\n  \/* ---------------- No need to edit below this line ---------------- *\/\n  var MONTHS = ['Jan','Feb','Mar','Apr','May','Jun','Jul','Aug','Sep','Oct','Nov','Dec'];\n  var SORT_LABEL = { newest: 'newest first', ending: 'ending soonest first', funder: 'by funder' };\n  function ym(s) { var p = String(s || '').split('\/'); return (+p[1] || 0) * 100 + (+p[0] || 0); }\n  function fmt(s) { var p = String(s || '').split('\/'); return (MONTHS[+p[0] - 1] || '') + ' ' + (p[1] || ''); }\n  function esc(s) { return String(s == null ? '' : s).replace(\/[&<>\"']\/g, function (c) { return { '&': '&amp;', '<': '&lt;', '>': '&gt;', '\"': '&quot;', \"'\": '&#39;' }[c]; }); }\n\n  function init(root) {\n    root.setAttribute('data-kl-ready', '');\n    var $ = function (k, scope) { return (scope || root).querySelector('[data-kl=\"' + k + '\"]'); };\n    var overlay = $('fp-overlay');\n    var openBtn = $('fp-open');\n    if (!overlay || !openBtn) return;\n\n    \/\/ Move panel to <body> so position:fixed isn't trapped by Elementor containers\n    document.querySelectorAll('.kl-fp-overlay[data-kl-moved]').forEach(function (o) { o.remove(); });\n    overlay.setAttribute('data-kl-moved', '');\n    document.body.appendChild(overlay);\n\n    var search = $('fp-search', overlay), filtersEl = $('fp-filters', overlay), countEl = $('fp-count', overlay), listEl = $('fp-list', overlay);\n    var sort = SORT_LABEL[CONFIG.sort] ? CONFIG.sort : 'newest';\n    var state = { q: '', group: 'All' };\n\n    var list = PROJECTS.map(function (p, i) { var o = {}; for (var k in p) o[k] = p[k]; o.i = i; return o; });\n    if (sort === 'newest') list.sort(function (a, b) { return ym(b.start) - ym(a.start); });\n    if (sort === 'ending') list.sort(function (a, b) { return ym(a.end) - ym(b.end); });\n    if (sort === 'funder') list.sort(function (a, b) { return a.funder.localeCompare(b.funder) || ym(b.start) - ym(a.start); });\n\n    \/\/ Section title + funder summary chips\n    $('fp-total').textContent = PROJECTS.length + ' active funded projects';\n    $('fp-summary').innerHTML = CONFIG.groups.map(function (g) {\n      var n = PROJECTS.filter(function (p) { return p.group === g; }).length;\n      return '<span class=\"kl-sum-chip\">' + esc(g) + '<span class=\"kl-n\">' + n + '<\/span><\/span>';\n    }).join('');\n\n    \/\/ Filter buttons\n    filtersEl.innerHTML = ['All'].concat(CONFIG.groups).map(function (g) {\n      return '<button type=\"button\" class=\"kl-fp-filter' + (g === 'All' ? ' is-active' : '') + '\" data-group=\"' + esc(g) + '\" aria-pressed=\"' + (g === 'All') + '\">' + esc(g === 'All' ? 'All funders' : g) + '<\/button>';\n    }).join('');\n    filtersEl.addEventListener('click', function (e) {\n      var b = e.target.closest('.kl-fp-filter'); if (!b) return;\n      state.group = b.getAttribute('data-group');\n      filtersEl.querySelectorAll('.kl-fp-filter').forEach(function (x) {\n        var on = x === b; x.classList.toggle('is-active', on); x.setAttribute('aria-pressed', on);\n      });\n      render();\n    });\n\n    search.addEventListener('input', function () { state.q = search.value; render(); });\n\n    function render() {\n      var q = state.q.trim().toLowerCase();\n      var vis = list.filter(function (p) {\n        return (state.group === 'All' || p.group === state.group) &&\n          (!q || [p.title, p.obj, p.award, p.place, p.funder].join(' ').toLowerCase().indexOf(q) !== -1);\n      });\n      countEl.textContent = vis.length + (vis.length === 1 ? 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