{"id":278,"date":"2026-10-27T04:57:45","date_gmt":"2026-10-27T04:57:45","guid":{"rendered":"https:\/\/karikarilab.org\/?page_id=278"},"modified":"2026-10-27T04:59:25","modified_gmt":"2026-10-27T04:59:25","slug":"clinical-insight","status":"publish","type":"page","link":"https:\/\/karikarilab.org\/?page_id=278","title":{"rendered":"Clinical Insight"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"278\" class=\"elementor elementor-278\" data-elementor-post-type=\"page\">\n\t\t\t\t<div class=\"elementor-element elementor-element-ac8e8a0 e-flex e-con-boxed e-con e-parent\" data-id=\"ac8e8a0\" data-element_type=\"container\" data-e-type=\"container\">\r\n\t\t\t\t\t<div class=\"e-con-inner\">\r\n\t\t\t\t<div class=\"elementor-element elementor-element-3092533 elementor-widget elementor-widget-html\" data-id=\"3092533\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t\t<!-- ============================================================\n  KARIKARI LAB \u2014 RESEARCH PROJECT PAGE: BIOMARKER DATA MINING (body)\n  Elementor HTML widget. 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flex:1 1 100%; min-width:0; }\n  .kl .kl-toc nav { flex-direction:row; overflow-x:auto; border-left:0; border-bottom:2px solid #E7E5DE; scrollbar-width:none; }\n  .kl .kl-toc nav::-webkit-scrollbar { display:none; }\n  .kl .kl-toc nav a { flex:none; padding:10px 16px 12px 0; margin-right:4px; white-space:nowrap; }\n  .kl .kl-main { flex-basis:100%; }\n}\n@media (max-width:600px){\n  .kl .kl-hero-media { aspect-ratio:4\/4.4; }\n  .kl .kl-hero-cap { flex-direction:column; align-items:flex-start; }\n  .kl .kl-pub { grid-template-columns:minmax(0,1fr); }\n  .kl .kl-pub-arrow { display:none; }\n  .kl .kl-next { align-items:flex-start; text-align:left; }\n  .kl .kl-back { width:100%; justify-content:center; }\n}\n\n<\/style>\n\n<!-- Root: add kl-no-nav and\/or kl-no-kickers to hide those parts -->\n<div class=\"kl kl-project\">\n\n  <!-- ================= HERO ================= -->\n  <section class=\"kl-hero\">\n    <div class=\"kl-wrap\">\n      <div>\n        <div class=\"kl-crumbs\">\n          <a href=\"#\">Research<\/a><!-- LINK: Research page URL -->\n          <span class=\"sep\">\/<\/span>\n          <span class=\"cur\">Biomarker data mining<\/span>\n        <\/div>\n        <div class=\"kl-hero-eyebrow\"><span class=\"kl-bar\"><\/span>Clinical implementation<\/div>\n        <h1 class=\"kl-hero-title\">Turning biomarker data into clinical insight<\/h1>\n        <p class=\"kl-hero-lede\">Using statistics and artificial intelligence to understand disease, risk, and dementia burden across populations.<\/p>\n        <div class=\"kl-tags\">\n          <span>Biomarkers<\/span>\n          <span>Clinical translation<\/span>\n          <span>Precision medicine<\/span>\n        <\/div>\n      <\/div>\n      <figure class=\"kl-hero-fig\">\n        <div class=\"kl-hero-media\">\n          <img decoding=\"async\" src=\"https:\/\/images.pexels.com\/photos\/6285362\/pexels-photo-6285362.jpeg?auto=compress&amp;cs=tinysrgb&amp;w=1400\" alt=\"Two clinicians reviewing data together on a computer screen\"><!-- IMAGE: hero image URL -->\n        <\/div>\n        <figcaption class=\"kl-hero-cap\">\n          <span class=\"kl-hero-badge\">From data to decisions<\/span>\n          <span class=\"kl-hero-credit\">Photo: Gustavo Fring \/ Pexels<\/span><!-- delete or edit credit -->\n        <\/figcaption>\n      <\/figure>\n    <\/div>\n  <\/section>\n\n  <!-- ================= BODY ================= -->\n  <section class=\"kl-body\">\n    <div class=\"kl-wrap\">\n\n      <!-- On this page (each href must match an article id below) -->\n      <aside class=\"kl-toc\">\n        <p class=\"kl-toc-label\">On this page<\/p>\n        <nav aria-label=\"On this page\">\n          <a href=\"#problem\">The problem<\/a>\n          <a href=\"#approach\">Our approach<\/a>\n          <a href=\"#matters\">Why it matters<\/a>\n          <a href=\"#next\">What's next<\/a>\n          <a href=\"#publications\">Key publications<\/a>\n          <a href=\"#team\">Team<\/a>\n        <\/nav>\n      <\/aside>\n\n      <div class=\"kl-main\">\n\n        <!-- ===== THE PROBLEM ===== -->\n        <article class=\"kl-sec\" id=\"problem\">\n          <h2 class=\"kl-sec-label\"><span class=\"kl-bar\"><\/span>The problem<\/h2>\n          <p class=\"kl-kicker\">What's the challenge, and why is it so hard to solve?<\/p>\n          <p class=\"kl-text\">Biomarker measurements generate rich information about neurodegenerative disease, but their value depends on how effectively they can be linked to brain pathology, clinical outcomes, and the diverse factors that shape dementia risk. Robust analytical approaches are needed to translate complex biomarker and population data into clinically meaningful insights that apply across different populations and disease contexts.<\/p>\n        <\/article>\n\n        <!-- ===== OUR APPROACH ===== -->\n        <article class=\"kl-sec\" id=\"approach\">\n          <h2 class=\"kl-sec-label\"><span class=\"kl-bar\"><\/span>Our approach<\/h2>\n          <p class=\"kl-kicker\">How are we tackling the challenge?<\/p>\n          <p class=\"kl-text\">We integrate data from our own studies with large publicly available datasets, leveraging traditional statistical methods, data mining, and artificial intelligence to translate biomarker measurements into clinical and biological insights. We evaluate how blood-based biomarkers relate to clinical diagnosis, amyloid and tau PET imaging, cognitive decline, and disease progression. We also use biomarkers as indicators of underlying disease processes to investigate how aging, sex, race and ancestry, social determinants of health, environmental exposures, brain injuries, and other health factors contribute to dementia risk, progression, and population-level disease burden.<\/p>\n        <\/article>\n\n        <!-- ===== WHY IT MATTERS ===== -->\n        <article class=\"kl-sec kl-sec-dark\" id=\"matters\">\n          <h2 class=\"kl-sec-label\"><span class=\"kl-bar\"><\/span>Why it matters<\/h2>\n          <p class=\"kl-kicker\">What difference could this make for patients and society?<\/p>\n          <div class=\"kl-stack\">\n            <p class=\"kl-text\">Blood-based biomarkers have the potential to transform dementia care by enabling more precise and personalized approaches to diagnosis, prognosis, and treatment. By linking biomarker profiles to clinical outcomes, brain pathology, and diverse risk factors, we can better understand why disease develops and progresses differently across individuals. These insights can support precision medicine strategies that tailor prevention, monitoring, and therapeutic interventions to each person's unique biological and environmental risk profile.<\/p>\n            <!-- OPTIONAL BULLETS: uncomment and edit to add a list\n            <ul class=\"kl-bullets\">\n              <li>First point<\/li>\n              <li>Second point<\/li>\n            <\/ul>\n            -->\n          <\/div>\n        <\/article>\n\n        <!-- ===== WHAT'S NEXT ===== -->\n        <article class=\"kl-sec\" id=\"next\">\n          <h2 class=\"kl-sec-label\"><span class=\"kl-bar\"><\/span>What's next<\/h2>\n          <p class=\"kl-kicker\">Once we've solved this, what do we want to explore next?<\/p>\n          <p class=\"kl-quote\">Next, we aim to translate our findings into clinical practice by turning integrated biomarker, imaging, and clinical data from diverse populations into validated tools that clinicians can use to detect, stage, and monitor disease and to personalize patient care.<\/p>\n        <\/article>\n\n        <!-- ===== KEY PUBLICATIONS ===== -->\n        <article class=\"kl-sec\" id=\"publications\">\n          <h2 class=\"kl-sec-label\"><span class=\"kl-bar\"><\/span>Key publications<\/h2>\n          <p class=\"kl-kicker mb24\">Where can I read more?<\/p>\n          <div class=\"kl-pubs\">\n\n            <!-- \u25bc PUBLICATION \u25bc -->\n            <a class=\"kl-pub\" href=\"https:\/\/doi.org\/10.64898\/2026.05.18.26353208\" target=\"_blank\" rel=\"noopener\"><!-- LINK -->\n              <span class=\"kl-pub-text\">\n                <span class=\"kl-pub-meta\">Zeng et al. \u00b7 <em>medRxiv<\/em> (preprint) \u00b7 2026<\/span>\n                <span class=\"kl-pub-sum\">CNS-selective plasma p-tau217 accurately captures Alzheimer's disease pathology and progression.<\/span>\n              <\/span>\n              <span class=\"kl-pub-arrow\" aria-hidden=\"true\">\u2197<\/span>\n            <\/a>\n            <!-- \u25b2 END PUBLICATION \u25b2 -->\n\n            <!-- \u25bc PUBLICATION \u25bc -->\n            <a class=\"kl-pub\" href=\"https:\/\/doi.org\/10.1002\/alz.70985\" target=\"_blank\" rel=\"noopener\"><!-- LINK -->\n              <span class=\"kl-pub-text\">\n                <span class=\"kl-pub-meta\">Brodman et al. \u00b7 <em>Alzheimer's &amp; Dementia<\/em> \u00b7 2025<\/span>\n                <span class=\"kl-pub-sum\">Plasma biomarkers, brain amyloid-beta pathology, and cortical thickness in a non-Hispanic White and Black\/African American middle-aged community cohort: the HCP-CoBRA study.<\/span>\n              <\/span>\n              <span class=\"kl-pub-arrow\" aria-hidden=\"true\">\u2197<\/span>\n            <\/a>\n            <!-- \u25b2 END PUBLICATION \u25b2 -->\n\n            <!-- \u25bc PUBLICATION \u25bc -->\n            <a class=\"kl-pub\" href=\"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1002\/alz.70409\" target=\"_blank\" rel=\"noopener\"><!-- LINK -->\n              <span class=\"kl-pub-text\">\n                <span class=\"kl-pub-meta\">Sehrawat et al. \u00b7 <em>Alzheimer's &amp; Dementia<\/em> \u00b7 2025<\/span>\n                <span class=\"kl-pub-sum\">Alternative-antibody Pitt-p-tau217 showed comparable amyloid classification performance to ALZpath in community cohorts.<\/span>\n              <\/span>\n              <span class=\"kl-pub-arrow\" aria-hidden=\"true\">\u2197<\/span>\n            <\/a>\n            <!-- \u25b2 END PUBLICATION \u25b2 -->\n\n            <!-- \u25bc PUBLICATION \u25bc -->\n            <a class=\"kl-pub\" href=\"https:\/\/doi.org\/10.1002\/alz.70916\" target=\"_blank\" rel=\"noopener\"><!-- LINK -->\n              <span class=\"kl-pub-text\">\n                <span class=\"kl-pub-meta\">Balogun et al. \u00b7 <em>Alzheimer's &amp; Dementia<\/em> \u00b7 2025<\/span>\n                <span class=\"kl-pub-sum\">Cross-cohort validation and cutpoint estimation of the Janssen plasma p-tau217+ assay in predominantly cognitively normal community studies.<\/span>\n              <\/span>\n              <span class=\"kl-pub-arrow\" aria-hidden=\"true\">\u2197<\/span>\n            <\/a>\n            <!-- \u25b2 END PUBLICATION \u25b2 -->\n\n          <\/div>\n        <\/article>\n\n        <!-- ===== TEAM ===== -->\n        <article class=\"kl-sec\" id=\"team\">\n          <h2 class=\"kl-sec-label\"><span class=\"kl-bar\"><\/span>Team<\/h2>\n          <p class=\"kl-kicker mb24\">Who's working on this?<\/p>\n          <div class=\"kl-team\">\n\n            <!-- \u25bc TEAM MEMBER \u25bc -->\n            <a class=\"kl-member\" href=\"\/about-us\/#ruyu-shi\">Ruyu Shi<span class=\"kl-arr\" aria-hidden=\"true\">\u2192<\/span><\/a><!-- LINK: profile URL -->\n            <!-- \u25b2 END TEAM MEMBER \u25b2 -->\n\n            <!-- \u25bc TEAM MEMBER \u25bc -->\n            <a class=\"kl-member\" href=\"\/about-us\/#anurag-raj\">Anurag Raj<span class=\"kl-arr\" aria-hidden=\"true\">\u2192<\/span><\/a><!-- LINK -->\n            <!-- \u25b2 END TEAM MEMBER \u25b2 -->\n\n            <!-- \u25bc TEAM MEMBER \u25bc -->\n            <a class=\"kl-member\" href=\"\/about-us\/#theresa-boots\">Theresa E. Boots<span class=\"kl-arr\" aria-hidden=\"true\">\u2192<\/span><\/a><!-- LINK -->\n            <!-- \u25b2 END TEAM MEMBER \u25b2 -->\n\n            <!-- \u25bc TEAM MEMBER \u25bc -->\n            <a class=\"kl-member\" href=\"\/about-us\/#xuemei-zeng\">Xuemei Zeng<span class=\"kl-arr\" aria-hidden=\"true\">\u2192<\/span><\/a><!-- LINK -->\n            <!-- \u25b2 END TEAM MEMBER \u25b2 -->\n\n          <\/div>\n        <\/article>\n\n        <!-- ===== PAGER ===== -->\n        <div class=\"kl-pager\">\n          <a class=\"kl-back\" href=\"#\">\u2190 All research projects<\/a><!-- LINK: Research page URL -->\n          <a class=\"kl-next\" href=\"#\"><!-- LINK: next project page URL -->\n            <span class=\"kl-next-label\">Next project<\/span>\n            <span class=\"kl-next-title\">Unlocking tau heterogeneity through post-translational modification biomarkers in plasma \u2192<\/span>\n          <\/a>\n        <\/div>\n\n      <\/div>\n    <\/div>\n  <\/section>\n<\/div>\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\r\n\t\t\t\t<\/div>\r\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Research \/ Biomarker data mining Clinical implementation Turning biomarker data into clinical insight Using statistics and artificial intelligence to understand disease, risk, and dementia burden across populations. Biomarkers Clinical translation Precision medicine From data to decisions Photo: Gustavo Fring \/ Pexels On this page The problem Our approach Why it matters What&#8217;s next Key publications [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-278","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/karikarilab.org\/index.php?rest_route=\/wp\/v2\/pages\/278","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/karikarilab.org\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/karikarilab.org\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/karikarilab.org\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/karikarilab.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=278"}],"version-history":[{"count":4,"href":"https:\/\/karikarilab.org\/index.php?rest_route=\/wp\/v2\/pages\/278\/revisions"}],"predecessor-version":[{"id":285,"href":"https:\/\/karikarilab.org\/index.php?rest_route=\/wp\/v2\/pages\/278\/revisions\/285"}],"wp:attachment":[{"href":"https:\/\/karikarilab.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=278"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}