{"id":105,"date":"2026-10-26T09:43:37","date_gmt":"2026-10-26T09:43:37","guid":{"rendered":"https:\/\/karikarilab.org\/?page_id=105"},"modified":"2026-10-28T11:53:01","modified_gmt":"2026-10-28T11:53:01","slug":"lab-services","status":"publish","type":"page","link":"https:\/\/karikarilab.org\/?page_id=105","title":{"rendered":"Lab Services"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"105\" class=\"elementor elementor-105\" data-elementor-post-type=\"page\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d835d69 e-flex e-con-boxed e-con e-parent\" data-id=\"d835d69\" data-element_type=\"container\" data-e-type=\"container\">\r\n\t\t\t\t\t<div class=\"e-con-inner\">\r\n\t\t\t\t<div class=\"elementor-element elementor-element-c208a66 elementor-widget elementor-widget-html\" data-id=\"c208a66\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t\t<!-- ============================================================\n  KARIKARI LAB \u2014 LAB SERVICES PAGE \u2014 Elementor HTML widget\n  ------------------------------------------------------------\n  \u2022 Paste into one Elementor \"HTML\" widget (full-width section\/container).\n  \u2022 The top bar + nav live in the separate header widget\n    (2-karikari-header.html). On this page, give the \"Lab services\"\n    nav link class=\"active\" there.\n  \u2022 IMAGES: each image has  src=\"PASTE-IMAGE-URL-HERE\".\n    Replace it with the full image URL (WordPress \u2192 Media Library \u2192\n    click the image \u2192 \"Copy URL to clipboard\").\n  \u2022 EMAIL: set LAB_EMAIL in the <script> at the bottom.\n  \u2022 Repeatable blocks are marked  \u25bc COPY FROM HERE \/ \u25b2 TO HERE.\n    Duplicate one to add an item, delete one to remove it.\n============================================================ -->\n<link rel=\"preconnect\" href=\"https:\/\/fonts.googleapis.com\">\n<link rel=\"preconnect\" href=\"https:\/\/fonts.gstatic.com\" crossorigin>\n<link href=\"https:\/\/fonts.googleapis.com\/css2?family=Archivo:wght@400;500;600;700;800;900&family=Spectral:wght@400;600&display=swap\" rel=\"stylesheet\">\n<style>\n\n\/* ---------- Base \/ full-width breakout (same as header widget) ---------- *\/\n.kl, .kl *, .kl *::before, .kl *::after { box-sizing:border-box; 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display:flex; flex-direction:column; gap:14px; }\n.kl .pf-body .maker { font-size:12px; font-weight:700; letter-spacing:0.22em; text-transform:uppercase; color:#5A5F66; }\n.kl .pf-body h3 { font-size:clamp(28px,2.8vw,36px); line-height:1.1; letter-spacing:-0.015em; color:#0C0D0F; }\n.kl .pf-body p { font-size:17px; line-height:1.6; color:#3C3F45; text-wrap:pretty; }\n.kl .tests { display:flex; flex-direction:column; border-top:1px solid #0C0D0F; margin-top:6px; }\n.kl .test { display:grid; grid-template-columns:repeat(auto-fit,minmax(min(100%,200px),1fr)); align-items:baseline; gap:4px 24px; padding:14px 0; border-bottom:1px solid #E7E5DE; }\n.kl .test b { font-weight:800; font-size:16px; }\n.kl .test span { font-size:15px; color:#5A5F66; }\n\n\/* ---------- Quote ---------- *\/\n.kl .quote { background:#F4F3EF; }\n.kl .quote .wrap { display:flex; flex-wrap:wrap; gap:40px clamp(40px,6vw,88px); align-items:flex-start; }\n.kl .q-intro { flex:1 1 320px; min-width:0; display:flex; flex-direction:column; gap:14px; }\n.kl .q-intro h2 { font-size:clamp(30px,3.2vw,40px); line-height:1.1; letter-spacing:-0.015em; }\n.kl .q-intro p { max-width:46ch; font-size:17px; line-height:1.6; color:#3C3F45; text-wrap:pretty; }\n.kl .q-intro p.alt { margin-top:8px; font-size:15px; color:#5A5F66; }\n.kl .q-intro a, .kl .q-done a { font-weight:700; }\n.kl .q-box { flex:1.4 1 440px; min-width:0; }\n.kl .q-form { display:grid; grid-template-columns:repeat(auto-fit,minmax(min(100%,240px),1fr)); gap:20px; padding:clamp(24px,3vw,36px); background:#FFFFFF; border-radius:14px; }\n.kl .q-form label { display:flex; flex-direction:column; gap:8px; font-size:13px; font-weight:700; letter-spacing:0.06em; text-transform:uppercase; color:#3C3F45; }\n.kl .q-form .full { grid-column:1\/-1; }\n.kl .q-form input, .kl .q-form textarea { width:100%; padding:13px 16px; margin:0; border:1px solid #CFCCC2; border-radius:8px; font-family:inherit; font-size:16px; font-weight:400; letter-spacing:normal; text-transform:none; color:#0C0D0F; background:#FFFFFF; outline:none; box-shadow:none; }\n.kl .q-form textarea { resize:vertical; }\n.kl .q-form input:focus, .kl .q-form textarea:focus { border-color:#1663CF; }\n.kl .q-form button { justify-self:start; background:#0C0D0F; color:#FFFFFF; border:0; border-radius:0; padding:15px 28px; font-family:inherit; font-weight:700; font-size:15px; letter-spacing:0.03em; cursor:pointer; transition:background .2s; }\n.kl .q-form button:hover { background:#1663CF; color:#FFFFFF; }\n.kl .q-done { display:none; flex-direction:column; gap:10px; padding:clamp(24px,3vw,36px); background:#FFFFFF; border-radius:14px; }\n.kl .q-done .h { font-size:26px; }\n.kl .q-done p { font-size:16px; line-height:1.6; color:#3C3F45; }\n.kl .q-box.sent .q-form { display:none; }\n.kl .q-box.sent .q-done { display:flex; }\n\n<\/style>\n\n<div class=\"kl kl-services\">\n\n  <!-- ================= HERO ================= -->\n  <section class=\"svc-hero\">\n    <div class=\"wrap\">\n      <div class=\"eyebrow\"><i><\/i><span>Services<\/span><\/div>\n      <h1>Laboratory services<\/h1>\n      <p class=\"lede\">Fee-for-service blood biomarker testing for researchers studying Alzheimer\u2019s disease and related dementias. We run validated assays on four platforms, on human samples.<\/p>\n      <div class=\"btns\">\n        <a href=\"#quote\" class=\"btn-y\">Request a quote<\/a>\n        <a href=\"#platforms\" class=\"btn-o\">See the test menu<\/a>\n      <\/div>\n    <\/div>\n  <\/section>\n\n  <!-- ================= WHAT WE MEASURE ================= -->\n  <section class=\"sec rule\">\n    <div class=\"wrap bm-stack\">\n      <div class=\"sec-head\">\n        <h2>What we measure<\/h2>\n        <span>Each biomarker reflects a different part of the disease process.<\/span>\n      <\/div>\n\n      <div class=\"bm-grid\">\n\n        <!-- \u25bc BIOMARKER \u2014 COPY FROM HERE -->\n        <div class=\"bm\">\n          <span class=\"n\">p-tau217<\/span>\n          <span class=\"t\">Amyloid &amp; tau pathology<\/span>\n          <p>Tau phosphorylated at threonine 217. One of the most accurate blood markers of Alzheimer\u2019s disease.<\/p>\n        <\/div>\n        <!-- \u25b2 BIOMARKER \u2014 TO HERE -->\n\n        <div class=\"bm\">\n          <span class=\"n\">p-tau217 \/ A\u03b242 ratio<\/span>\n          <span class=\"t\">Amyloid status<\/span>\n          <p>Pairs a marker that rises with one that falls in Alzheimer\u2019s, sharpening the separation between amyloid-positive and amyloid-negative people.<\/p>\n        <\/div>\n\n        <div class=\"bm\">\n          <span class=\"n\">BD-p-tau217<\/span>\n          <span class=\"t\">Brain-specific tau<\/span>\n          <p>Brain-derived p-tau217 targets tau made in the brain, not in peripheral tissues, for a cleaner signal of Alzheimer\u2019s-related change.<\/p>\n        <\/div>\n\n        <div class=\"bm\">\n          <span class=\"n\">eMTBR-tau<\/span>\n          <span class=\"t\">Tau tangles<\/span>\n          <p>An extended microtubule-binding region tau fragment that reaches the blood as tau tangles form. Tracks tangle pathology rather than amyloid.<\/p>\n        <\/div>\n\n        <div class=\"bm\">\n          <span class=\"n\">A\u03b242<\/span>\n          <span class=\"t\">Amyloid plaques<\/span>\n          <p>Amyloid-beta 1\u201342. Lower blood levels reflect amyloid building up as plaques in the brain.<\/p>\n        <\/div>\n\n        <div class=\"bm\">\n          <span class=\"n\">NfL<\/span>\n          <span class=\"t\">Nerve-cell damage<\/span>\n          <p>Neurofilament light chain is released when axons are injured. Not specific to one disease, but a sensitive gauge of active neurodegeneration.<\/p>\n        <\/div>\n\n        <div class=\"bm\">\n          <span class=\"n\">GFAP<\/span>\n          <span class=\"t\">Astrocyte activation<\/span>\n          <p>Glial fibrillary acidic protein signals reactive astrocytes, one of the brain\u2019s earliest responses to amyloid.<\/p>\n        <\/div>\n\n        <div class=\"bm\">\n          <span class=\"n\">APOE (protein)<\/span>\n          <span class=\"t\">Genetic risk<\/span>\n          <p>Apolipoprotein E measured in blood. Its \u03b54 form is the strongest common genetic risk factor for late-onset Alzheimer\u2019s.<\/p>\n        <\/div>\n\n        <div class=\"bm\">\n          <span class=\"n\">APOE genotype<\/span>\n          <span class=\"t\">Genetic risk<\/span>\n          <p>Identifies \u03b52, \u03b53 and \u03b54 alleles. Used to stratify cohorts and relevant to safety monitoring with anti-amyloid therapies.<\/p>\n        <\/div>\n\n      <\/div>\n    <\/div>\n  <\/section>\n\n  <!-- ================= TEST MENU BY PLATFORM ================= -->\n  <section id=\"platforms\" class=\"sec\">\n    <div class=\"wrap pf-stack\">\n      <div class=\"sec-head\">\n        <h2>Test menu by platform<\/h2>\n        <span>All tests run on human samples.<\/span>\n      <\/div>\n\n      <!-- \u25bc PLATFORM \u2014 COPY FROM HERE\n           Image: replace PASTE-IMAGE-URL-HERE with the image's full URL.\n           Product shots on white: add class \"contain\" to .pf-img (shows whole image, padded).\n           Photos: leave without \"contain\" (fills the frame, cropped). -->\n      <article id=\"lumipulse\" class=\"pf\">\n        <div class=\"pf-img\">\n          <!-- IMAGE LINK: Lumipulse G analyzer -->\n          <img decoding=\"async\" src=\"https:\/\/karikarilab.org\/wp-content\/uploads\/2026\/10\/lumipulse-g1200.png\" alt=\"Fujirebio Lumipulse G analyzer\" loading=\"lazy\">\n        <\/div>\n        <div class=\"pf-body\">\n          <span class=\"maker\">Fujirebio<\/span>\n          <h3>Lumipulse G<\/h3>\n          <p>A fully automated chemiluminescent immunoassay system used in clinical laboratories. Its p-tau217 \/ A\u03b242 plasma ratio was the first blood test cleared by the FDA to aid Alzheimer\u2019s diagnosis.<\/p>\n          <div class=\"tests\">\n            <!-- one .test row per assay \u2014 duplicate or delete rows as needed -->\n            <div class=\"test\"><b>p-tau217<\/b><span>Lumipulse G pTau 217, plasma<\/span><\/div>\n            <div class=\"test\"><b>p-tau217 \/ A\u03b242 ratio<\/b><span>Lumipulse G pTau 217 and \u03b2-Amyloid 1-42 plasma ratio<\/span><\/div>\n            <div class=\"test\"><b>NfL<\/b><span>Lumipulse G NfL, plasma<\/span><\/div>\n            <div class=\"test\"><b>GFAP<\/b><span>Lumipulse G GFAP, plasma<\/span><\/div>\n          <\/div>\n        <\/div>\n      <\/article>\n      <!-- \u25b2 PLATFORM \u2014 TO HERE -->\n\n      <article id=\"dxi\" class=\"pf\">\n        <div class=\"pf-img\">\n          <!-- IMAGE LINK: DxI 9000 analyzer -->\n          <img decoding=\"async\" src=\"https:\/\/karikarilab.org\/wp-content\/uploads\/2026\/10\/dxi9000.png\" alt=\"Beckman Coulter DxI 9000 analyzer\" loading=\"lazy\">\n        <\/div>\n        <div class=\"pf-body\">\n          <span class=\"maker\">Beckman Coulter<\/span>\n          <h3>DxI 9000 Immunoassay Analyzer<\/h3>\n          <p>A high-throughput, highly sensitive automated immunoassay analyzer built for large hospital laboratories, suited to big cohorts and fast turnaround.<\/p>\n          <div class=\"tests\">\n            <div class=\"test\"><b>BD-p-tau217<\/b><span>DxI 9000 brain-derived p-tau217<\/span><\/div>\n            <div class=\"test\"><b>NfL<\/b><span>DxI 9000 NfL<\/span><\/div>\n            <div class=\"test\"><b>GFAP<\/b><span>DxI 9000 GFAP<\/span><\/div>\n            <div class=\"test\"><b>APOE<\/b><span>DxI 9000 APOE<\/span><\/div>\n          <\/div>\n        <\/div>\n      <\/article>\n\n      <article id=\"nulisa\" class=\"pf\">\n        <div class=\"pf-img contain\">\n          <!-- IMAGE LINK: ARGO HT \/ NULISA system -->\n          <img decoding=\"async\" src=\"https:\/\/karikarilab.org\/wp-content\/uploads\/2026\/10\/argo-ht.png\" alt=\"Alamar Biosciences ARGO HT \/ NULISA system\" loading=\"lazy\">\n        <\/div>\n        <div class=\"pf-body\">\n          <span class=\"maker\">Alamar Biosciences<\/span>\n          <h3>NULISA<\/h3>\n          <p>An ultra-sensitive proximity-ligation immunoassay that detects proteins at attomolar levels and measures several biomarkers from one small sample.<\/p>\n          <div class=\"tests\">\n            <div class=\"test\"><b>BD-p-tau217<\/b><span>NULISAqpcr BD-pTau217 Assay (singleplex)<\/span><\/div>\n            <div class=\"test\"><b>eMTBR-tau<\/b><span>NULISAqpcr eMTBR-Tau Assay (singleplex)<\/span><\/div>\n            <div class=\"test\"><b>BD-p-tau217, A\u03b242, NfL, GFAP, APOE4 carrier status<\/b><span>NULISAqpcr AD 5-plex Assay<\/span><\/div>\n          <\/div>\n        <\/div>\n      <\/article>\n\n      <article id=\"pcr\" class=\"pf\">\n        <div class=\"pf-img contain\">\n          <!-- IMAGE LINK: PCR instrument (e.g. QuantStudio 3) -->\n          <img decoding=\"async\" src=\"https:\/\/karikarilab.org\/wp-content\/uploads\/2026\/10\/quantstudio3.png\" alt=\"PCR instrument\" loading=\"lazy\">\n        <\/div>\n        <div class=\"pf-body\">\n          <span class=\"maker\">Genotyping<\/span>\n          <h3>PCR<\/h3>\n          <p>Polymerase chain reaction reads a person\u2019s APOE genes directly from DNA, giving a definitive genotype to pair with blood biomarker results.<\/p>\n          <div class=\"tests\">\n            <div class=\"test\"><b>APOE \u03b52, \u03b53 and \u03b54<\/b><span>APOE genotyping by PCR<\/span><\/div>\n          <\/div>\n        <\/div>\n      <\/article>\n\n    <\/div>\n  <\/section>\n\n  <!-- ================= REQUEST A QUOTE ================= -->\n  <section id=\"quote\" class=\"sec quote\">\n    <div class=\"wrap\">\n      <div class=\"q-intro\">\n        <h2>Request a quote<\/h2>\n        <p>Tell us about your samples and questions, and we\u2019ll recommend the right tests and send a quote.<\/p>\n        <p class=\"alt\">Prefer email? <a class=\"js-mail\" data-subject=\"Laboratory services enquiry\" href=\"#\"><span class=\"js-mail-text\"><\/span><\/a><\/p>\n      <\/div>\n\n      <div class=\"q-box\">\n        <!-- Form opens the visitor's email app with the request filled in (no server needed).\n             To use an Elementor Form or a form plugin instead, replace this <form> with its shortcode. -->\n        <form class=\"q-form\" novalidate>\n          <label>Name<input name=\"name\" required autocomplete=\"name\"><\/label>\n          <label>Email<input name=\"email\" type=\"email\" required autocomplete=\"email\"><\/label>\n          <label>Institution<input name=\"institution\" autocomplete=\"organization\"><\/label>\n          <label>Number of samples<input name=\"samples\" inputmode=\"numeric\"><\/label>\n          <label class=\"full\">Tests of interest and sample type<textarea name=\"message\" rows=\"5\" required><\/textarea><\/label>\n          <div class=\"full\"><button type=\"submit\">Send request<\/button><\/div>\n        <\/form>\n\n        <div class=\"q-done\">\n          <span class=\"h\">Thank you<\/span>\n          <p>Your email app should open with your request ready to send. If it didn\u2019t, email us at <a class=\"js-mail\" href=\"#\"><span class=\"js-mail-text\"><\/span><\/a>.<\/p>\n        <\/div>\n      <\/div>\n    <\/div>\n  <\/section>\n\n<\/div>\n\n<script>\n(function () {\n  \/* >>> EDIT THIS <<< *\/\n  var LAB_EMAIL = 'karikari-lab@upmc.edu';\n\n  var root = document.querySelector('.kl-services');\n  if (!root) return;\n\n  \/\/ Email links\n  root.querySelectorAll('.js-mail').forEach(function (a) {\n    var s = a.getAttribute('data-subject');\n    a.href = 'mailto:' + LAB_EMAIL + (s ? '?subject=' + encodeURIComponent(s) : '');\n  });\n  root.querySelectorAll('.js-mail-text').forEach(function (el) { el.textContent = LAB_EMAIL; });\n\n  \/\/ Quote form -> pre-filled email\n  var form = root.querySelector('.q-form');\n  var box  = root.querySelector('.q-box');\n  if (form) form.addEventListener('submit', function (e) {\n    e.preventDefault();\n    if (!form.checkValidity()) { form.reportValidity(); return; }\n    var f = new FormData(form);\n    var v = function (k) { return (f.get(k) || '').toString().trim(); };\n    var body = 'Name: ' + v('name') + '\\nEmail: ' + v('email') +\n               '\\nInstitution: ' + v('institution') +\n               '\\nNumber of samples: ' + v('samples') + '\\n\\n' + v('message');\n    window.location.href = 'mailto:' + LAB_EMAIL +\n      '?subject=' + encodeURIComponent('Quote request: ' + (v('institution') || v('name'))) +\n      '&body=' + encodeURIComponent(body);\n    box.classList.add('sent');\n  });\n})();\n<\/script>\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\r\n\t\t\t\t<\/div>\r\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-105","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/karikarilab.org\/index.php?rest_route=\/wp\/v2\/pages\/105","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/karikarilab.org\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/karikarilab.org\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/karikarilab.org\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/karikarilab.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=105"}],"version-history":[{"count":19,"href":"https:\/\/karikarilab.org\/index.php?rest_route=\/wp\/v2\/pages\/105\/revisions"}],"predecessor-version":[{"id":385,"href":"https:\/\/karikarilab.org\/index.php?rest_route=\/wp\/v2\/pages\/105\/revisions\/385"}],"wp:attachment":[{"href":"https:\/\/karikarilab.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=105"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}